Apheresis for senescence: Targeting the senescence-associated secretory phenotype to delay aging and age-related diseases

IF 12.4 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2025-07-10 DOI:10.1016/j.arr.2025.102832

Yamac Akgun

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引用次数: 0

Abstract

Aging is driven by cellular senescence and chronic inflammation, largely mediated by the senescence-associated secretory phenotype (SASP). SASP factors promote inflammaging, impair tissue homeostasis, and contribute to age-related diseases such as cardiovascular disease, neurodegeneration, and cancer. Current anti-aging strategies focus on senolytics or SASP inhibitors, yet these approaches have limitations. We discuss therapeutic plasma exchange (TPE) and selective apheresis, as interventions to mitigate SASP-driven aging. TPE removes inflammatory cytokines, metabolic waste, and senescence-associated proteins, while replenishing rejuvenating factors. Selective apheresis could enhance precision by targeting specific SASP components. By reducing systemic inflammation and restoring a youthful proteomic environment, these strategies may improve immune function, tissue regeneration, and overall healthspan. This review explores the mechanistic basis of SASP in aging and evaluates the potential of apheresis-based therapies as viable interventions to delay aging and age-related disease progression.

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针对衰老相关的分泌表型，延缓衰老和衰老相关疾病

衰老是由细胞衰老和慢性炎症驱动的，主要由衰老相关分泌表型（SASP）介导。SASP因子促进炎症，损害组织稳态，并导致与年龄相关的疾病，如心血管疾病、神经变性和癌症。目前的抗衰老策略主要集中在抗衰老药物或SASP抑制剂上，但这些方法都有局限性。我们讨论了治疗性血浆交换（TPE）和选择性血浆分离，作为干预措施，以减轻sasp驱动的衰老。TPE去除炎症细胞因子、代谢废物和衰老相关蛋白，同时补充恢复活力的因子。选择性分离可以通过靶向特定的SASP成分来提高精密度。通过减少全身炎症和恢复年轻的蛋白质组学环境，这些策略可以改善免疫功能、组织再生和整体健康。这篇综述探讨了SASP在衰老中的机制基础，并评估了基于血液分离的治疗方法作为延缓衰老和年龄相关疾病进展的可行干预措施的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.