A single theory for the evolution of sex chromosomes and the two rules of speciation

IF 44.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2025-07-10 DOI:10.1126/science.ado9032

Thomas Lenormand, Denis Roze

引用次数: 0

Abstract

Sex chromosomes are involved in three major empirical patterns: (i) Y (or W) chromosomes are often nonrecombining and degenerate; (ii) heterogametic offspring (XY or ZW) from interspecific crosses are more often sterile or inviable compared with homogametic offspring (Haldane’s rule); and (iii) the X (or Z) has a disproportionately large effect on reproductive isolation between species compared with autosomes (the large X effect). Each observation has received its own tailored explanation involving multiple genetic and evolutionary causes. In this work, we show that these empirical patterns all emerge from a single theory for sex chromosome evolution incorporating the coevolution of cis- and trans-acting regulators of gene expression and leading to systematic misexpression of dosage-compensated genes in heterogametic F1 hybrids, for both young and old sex chromosomes.

Abstract Image

查看原文本刊更多论文

性染色体进化的单一理论和物种形成的两条规则

性染色体涉及三种主要的经验模式：(i) Y（或W）染色体通常不重组和退化；（ii）种间杂交的异种杂交后代（XY或ZW）与同种杂交后代相比，往往不育或不能存活（霍尔丹规则）；（iii）与常染色体相比，X（或Z）对物种间的生殖隔离有不成比例的大影响（大X效应）。每个观察结果都有自己的解释，涉及多种遗传和进化原因。在这项工作中，我们表明，这些经验模式都来自于性染色体进化的单一理论，包括基因表达的顺式和反式调节因子的共同进化，并导致异配子F1杂交中剂量补偿基因的系统性错误表达，无论是年轻的还是年老的性染色体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

期刊介绍： Science is a leading outlet for scientific news, commentary, and cutting-edge research. Through its print and online incarnations, Science reaches an estimated worldwide readership of more than one million. Science’s authorship is global too, and its articles consistently rank among the world's most cited research. Science serves as a forum for discussion of important issues related to the advancement of science by publishing material on which a consensus has been reached as well as including the presentation of minority or conflicting points of view. Accordingly, all articles published in Science—including editorials, news and comment, and book reviews—are signed and reflect the individual views of the authors and not official points of view adopted by AAAS or the institutions with which the authors are affiliated. Science seeks to publish those papers that are most influential in their fields or across fields and that will significantly advance scientific understanding. Selected papers should present novel and broadly important data, syntheses, or concepts. They should merit recognition by the wider scientific community and general public provided by publication in Science, beyond that provided by specialty journals. Science welcomes submissions from all fields of science and from any source. The editors are committed to the prompt evaluation and publication of submitted papers while upholding high standards that support reproducibility of published research. Science is published weekly; selected papers are published online ahead of print.