Polyoxygenated Stigmastane-Type Steroids from the Whole Plant of Vernonia glabra (Steetz) Vatke (Asteraceae) and Their Antibacterial and Antioxidant Activities.

IF 3.6 2区生物学 Q2 CHEMISTRY, MEDICINAL

Journal of Natural Products Pub Date : 2025-07-25 Epub Date: 2025-07-09 DOI:10.1021/acs.jnatprod.5c00408

Voutro Kana Takeuneu, Paul Eckhardt, Borice Tapondjou Tsafack, Niklas Ehlenz, Ulrich Joël Tsopmene, Aphalaine Pinchemell Tiombou Donkia, Beaudelaire Kemvoufo Ponou, Jean Paul Dzoyem, Rémy Bertrand Teponno, Dieter Schollmeyer, Till Opatz, Tapondjou Azefack Leon

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引用次数: 0

Abstract

Six hitherto unreported polyoxygenated stigmastane-type steroids, vernoglabrosterols A and B (1 and 2), and vernoglabrosides A-D (3-6), along with two known analogues (7 and 8), were isolated from the ethanolic extract of the whole plant of Vernonia glabra (Steetz) Vatke (Asteraceae). Their structural elucidation was achieved by analysis of spectroscopic and spectrometric data, X-ray crystallography, as well as comparison to data reported in the literature. Compounds 3, 5, and 6 displayed significant DPPH scavenging activity, with IC₅₀ values of 2.49, 4.26, and 4.53 μg/mL, respectively. All of the tested compounds showed significant activities as judged by the FRAP assay compared to l-ascorbic acid. This is the first report of polyoxygenated stigmastane-type steroids C-6/C-7 oxygenated and 24,28-diol from the genus Vernonia.

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龙葵（Vernonia glabra）（Steetz） Vatke （Asteraceae）全株多氧柱头甾类化合物及其抑菌和抗氧化活性

从野田vernonia glabra (Steetz) Vatke （Asteraceae）全株乙醇提取物中分离得到6个迄今未报道的多氧柱头甾类化合物，vernoglabrosterols A和B(1和2),vernoglabrosterides A- d(3-6)，以及2个已知的类似物（7和8）。通过分析光谱和光谱数据、x射线晶体学以及与文献中报道的数据进行比较，实现了它们的结构阐明。化合物3、5和6具有明显的DPPH清除活性，IC50值分别为2.49、4.26和4.53 μg/mL。与l-抗坏血酸相比，所有被测试的化合物都显示出显著的活性。本文首次报道了从Vernonia属植物中分离到的多氧甾体甾类化合物C-6/C-7和24,28-二醇。

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来源期刊

Journal of Natural Products 生物-药学

CiteScore

9.10

自引率

5.90%

发文量

294

审稿时长

2.3 months

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.