Multimicronutrient and omega-3 fatty acid supplementation reduces low-grade inflammation in older participants: An exploratory study

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research Pub Date : 2025-06-19 DOI:10.1016/j.nutres.2025.06.005

Felix Kerlikowsky , Karsten Krüger , Andreas Hahn , Jan Philipp Schuchardt

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引用次数: 0

Abstract

Aging is associated with chronic low-grade inflammation, while the status of anti-inflammatory (INFLA) micronutrients such as long-chain omega-3 fatty acids (n-3 PUFA), vitamin D, folate, and cobalamin is often low in older people. We hypothesized that n-3 PUFA and certain micronutrients reduce low-grade inflammation in older participants. To test this hypothesis the aim of this randomised, double-blinded, 12-week intervention study involving 112 healthy and physically active older participants (75.6 ± 3.9 years) was to investigate the effect of a multimicronutrient and n-3 PUFA supplementation in physiological doses (i.e., 400 µg folic acid, 100 µg cobalamin, 50 µg cholecalciferol, and 1000 mg eicosapentaenoic acid + docosahexaenoic acid per day) on INFLA biomarkers, which were aggregated in the INFLA score. Dietary intake data were converted into the energy-adjusted dietary inflammatory index (E-DII). A significant increase in the nutrient status biomarkers Omega-3 Index, serum 25-hydroxycholecalciferol, red blood cell folate, and holotranscobalamin was observed in the intervention group compared to the placebo group (all P < .001). In a multiadjusted model (age, sex, body mass index, E-DII, Omega-3 Index), the intervention significantly decreased the INFLA score compared to placebo (P = .036). Participants with a more pro-INFLA E-DII at baseline and higher age showed a greater decrease in the INFLA score than those with a more anti-INFLA E-DII (P = .028) and lower age (P = .043). An effect of multimicronutrient + n-3 PUFA supplementation seems to be more pronounced in older participants with higher age and those with a pro-INFLA background diet.

Trial registration: This study is officially recorded in the German Clinical Trials Register (DRKS00021302, registration date: 23.04.2020).

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补充多微量营养素和omega-3脂肪酸可减少老年参与者的低度炎症：一项探索性研究

衰老与慢性低度炎症有关，而抗炎（INFLA）微量营养素如长链omega-3脂肪酸（n-3 PUFA）、维生素D、叶酸和钴胺素在老年人中通常较低。我们假设n-3 PUFA和某些微量营养素可以减少老年参与者的低度炎症。为了测试这个假说的目的随机,双盲,12周的干预研究涉及112名健康和体力活动老参与者(75.6±3.9岁)被调查的影响multimicronutrient和n - 3 PUFA的补充生理剂量(即400µg叶酸,100µg维生素b12, 50µg维生素d3,和1000毫克每天二十碳五烯酸+二十二碳六烯酸)INFLA生物标记,聚合在INFLA得分。将饮食摄入数据转换为能量调节饮食炎症指数（E-DII）。与安慰剂组相比，干预组的营养状态生物标志物Omega-3指数、血清25-羟基胆钙化醇、红细胞叶酸和全钴胺素显著增加(P <；措施)。在多因素调整模型（年龄、性别、体重指数、E-DII、Omega-3指数）中，与安慰剂相比，干预显著降低了INFLA评分（P = 0.036）。在基线时，E-DII水平较高且年龄较大的受试者，其INFLA评分的下降幅度大于抗E-DII水平较高的受试者（P = 0.028）和年龄较小的受试者（P = 0.043）。多微量营养素+ n-3 PUFA补充剂的效果似乎在年龄较大的老年参与者和具有促infla背景饮食的参与者中更为明显。试验注册：本研究已正式记录在德国临床试验注册（DRKS00021302，注册日期：23.04.2020）。

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来源期刊

Nutrition Research 医学-营养学

CiteScore

7.60

自引率

2.20%

发文量

107

审稿时长

58 days

期刊介绍： Nutrition Research publishes original research articles, communications, and reviews on basic and applied nutrition. The mission of Nutrition Research is to serve as the journal for global communication of nutrition and life sciences research on diet and health. The field of nutrition sciences includes, but is not limited to, the study of nutrients during growth, reproduction, aging, health, and disease. Articles covering basic and applied research on all aspects of nutrition sciences are encouraged, including: nutritional biochemistry and metabolism; metabolomics, nutrient gene interactions; nutrient requirements for health; nutrition and disease; digestion and absorption; nutritional anthropology; epidemiology; the influence of socioeconomic and cultural factors on nutrition of the individual and the community; the impact of nutrient intake on disease response and behavior; the consequences of nutritional deficiency on growth and development, endocrine and nervous systems, and immunity; nutrition and gut microbiota; food intolerance and allergy; nutrient drug interactions; nutrition and aging; nutrition and cancer; obesity; diabetes; and intervention programs.