Edible beeswax-flaxseed oil nanostructured lipid carriers for improved β-sitosterol bioaccessibility: structural advantages and controlled release in dynamic digestion

IF 8.5 1区农林科学 Q1 CHEMISTRY, APPLIED

Food Chemistry Pub Date : 2025-07-09 DOI:10.1016/j.foodchem.2025.145492

Lukai Ma , Zijian Li , Linjing Li , Xianhong Bi , Gengsheng Xiao , Linlin Li

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引用次数: 0

Abstract

This study developed nanostructured lipid carriers (NLCs) using edible beeswax and flaxseed oil to encapsulate β-sitosterol. Structural analysis revealed the formation of a less ordered lipid matrix with reduced crystallinity compared to pure beeswax, contributing to a high encapsulation efficiency of 92 %. Optimal formulation (beeswax: flaxseed oil 3:2, Tween 80: Polyglycerol fatty acid(PGE) 4:1 totaling 7 % emulsifier) and processing parameters (10 min homogenization, 200 W ultrasonic power for 4 min) yielded stable nanoparticles maintaining physical stability for 40 days across varying pH and temperature. In vitro digestion demonstrated that the NLCs effectively protected β-sitosterol from gastric degradation and enabled controlled intestinal release, achieving significantly higher bioaccessibility (43.9 %) compared to free β-sitosterol (12.1 %). These results highlight beeswax-flaxseed oil NLCs as a promising delivery system for enhancing the bioaccessibility of hydrophobic bioactive in functional foods.

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可食性蜂蜡-亚麻籽油纳米结构脂质载体改善β-谷甾醇生物可及性：结构优势和动态消化控制释放

本研究利用可食用蜂蜡和亚麻籽油制备了纳米结构脂质载体（nlc），包封β-谷甾醇。结构分析显示，与纯蜂蜡相比，形成的脂质基质的结晶度较低，结晶度较低，导致包封效率高达92% %。最佳配方（蜂蜡：亚麻籽油3:2，t80：聚甘油脂肪酸（PGE） 4:1，共7 %乳化剂）和工艺参数（均质10 min， 200 W超声功率4 min）产生了稳定的纳米颗粒，在不同的pH和温度下保持40 天的物理稳定性。体外消化表明，NLCs有效地保护β-谷甾醇不受胃降解，并能控制肠道释放，与游离β-谷甾醇（12.1% %）相比，具有显著更高的生物可及性（43.9 %）。这些结果表明蜂蜡-亚麻籽油ncs是一种很有前途的增强疏水生物活性在功能食品中的生物可及性的递送系统。

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来源期刊

Food Chemistry 工程技术-食品科技

CiteScore

16.30

自引率

10.20%

发文量

3130

审稿时长

122 days

期刊介绍： Food Chemistry publishes original research papers dealing with the advancement of the chemistry and biochemistry of foods or the analytical methods/ approach used. All papers should focus on the novelty of the research carried out.