Triterpene Glycosides Tricycloiridals A-D with Cytotoxicity Isolated from Fungus Chrysosporium sp. YX1242.

IF 3.3 2区生物学 Q2 CHEMISTRY, MEDICINAL

Journal of Natural Products Pub Date : 2025-07-07 DOI:10.1021/acs.jnatprod.5c00496

Kang Chen, Kainan Song, Xianzhi Jiang, Yuquan Xu

引用次数: 0

Abstract

Keratinophilic fungi are significant pathogens that cause dermatomycoses. Here, we report the discovery of four novel triterpene glycosides, tricycloiridals A-D (1-4), from the keratinophilic fungus Chrysosporium sp. YX1242, guided by mass-spectrometry-based molecular networking. Their structures, featuring unprecedented triterpene skeletons, were elucidated through comprehensive NMR, HRESIMS, and Snatzke's and advanced Mosher's methods. Notably, compound 1 exhibited potent cytotoxicity against human keratinocytes HaCaT (IC₅₀ = 2.50 ± 0.2 μM), suggesting a potential role as a virulence factor in fungal pathogenesis. Additionally, bioinformatic analysis was used to predict the biosynthetic gene cluster responsible for these triterpene glycosides.

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真菌Chrysosporium sp. YX1242中具有细胞毒性的三萜苷类三环吡啶A-D

嗜角真菌是引起皮肤真菌病的重要病原体。在这里，我们报告了从嗜角真菌Chrysosporium sp. YX1242中发现的四种新型三萜苷，三环吡啶A-D(1-4)，基于质谱的分子网络。它们的结构，具有前所未有的三萜骨架，通过综合NMR， hresms，以及Snatzke和先进的Mosher方法进行了阐明。值得注意的是，化合物1对人角质形成细胞HaCaT表现出强大的细胞毒性（IC50 = 2.50±0.2 μM），表明其可能是真菌发病的毒力因子。此外，生物信息学分析用于预测负责这些三萜苷的生物合成基因簇。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Natural Products 生物-药学

CiteScore

9.10

自引率

5.90%

发文量

294

审稿时长

2.3 months

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.