Electrospun Food Nanofibers for Hormonal Delivery: New Strategy in Sustainable Pharmaceutical Delivery System.

IF 2.8 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Deepak Kumar, Rishabha Malviya, Sathvik Belagodu Sridhar, Javedh Shareef, Tarun Wadhwa, Mullaicharam Bhupathyraaj, Musarrat Husain Warsi
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引用次数: 0

Abstract

Electrospinning is an innovative process that produces polymeric fibres for a variety of purposes, including controlled hormone administration. These fibres are made from biopolymers like chitosan, cellulose, alginate, and starch, and have attracted interest for their capacity to encapsulate hormones and release them in a regulated way, therefore Increasing bioavailability and stability. The article investigates the utilization of smart electrospun fibers for hormone delivery, alongside a focus on their potential to improve therapeutic results. Electrospun fibres can encapsulate hormones such as insulin, melatonin, and contraceptives for regulated and prolonged release. This method addresses difficulties in traditional hormone delivery, like frequent insulin injections or hormone instability in biological circumstances. Techniques like coaxial electrospinning enable the development of core-shell structures, which further optimize release profiles. The use of these fibres for diabetic management, wound healing, and long-term contraception represents substantial advances in patient care. The flexibility of fibres also allows for precise regulation of drug release kinetics, which improves the efficacy of hormone therapy while reducing adverse effects. Smart electrospun food fibres have enormous promise for the future of hormone administration, providing longer-lasting, more focused, and effective therapies. Their flexibility, along with ongoing advances in electrospinning processes, positions them as a viable tool in contemporary medicine.

电纺丝食品纳米纤维用于激素输送:可持续药物输送系统的新策略。
静电纺丝是一种创新的工艺,可以生产多种用途的聚合纤维,包括控制激素的施用。这些纤维由壳聚糖、纤维素、海藻酸盐和淀粉等生物聚合物制成,它们能够包裹激素并以一种受调节的方式释放激素,从而提高生物利用度和稳定性,因此引起了人们的兴趣。本文研究了智能电纺丝纤维用于激素输送的利用,以及它们改善治疗结果的潜力。电纺丝纤维可以包裹胰岛素、褪黑激素和避孕药等激素,以调节和延长释放。这种方法解决了传统激素输送的困难,如频繁注射胰岛素或生物环境下激素不稳定。同轴静电纺丝等技术使核壳结构得以发展,从而进一步优化释放剖面。这些纤维用于糖尿病管理、伤口愈合和长期避孕,代表了患者护理方面的重大进步。纤维的柔韧性也允许药物释放动力学的精确调节,这提高了激素治疗的功效,同时减少了不良反应。智能电纺丝食物纤维对激素管理的未来有着巨大的希望,提供更持久、更集中、更有效的治疗方法。它们的灵活性,以及静电纺丝工艺的不断进步,使它们成为当代医学中可行的工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.30
自引率
0.00%
发文量
302
审稿时长
2 months
期刊介绍: Current Pharmaceutical Design publishes timely in-depth reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field. Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.
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