Diabetes-Induced Dysregulation of Peripapillary and Macular Neurovascular Units.

IF 4.7 2区 医学 Q1 OPHTHALMOLOGY
Mizuho Mitamura, Satoru Kase, Hiroaki Endo, Michiyuki Saito, Satoshi Katsuta, Susumu Ishida
{"title":"Diabetes-Induced Dysregulation of Peripapillary and Macular Neurovascular Units.","authors":"Mizuho Mitamura, Satoru Kase, Hiroaki Endo, Michiyuki Saito, Satoshi Katsuta, Susumu Ishida","doi":"10.1167/iovs.66.9.10","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to investigate the impact of diabetic retinopathy (DR) on macular and peripapillary neurovascular units (NVUs) by assessing optical coherence tomography (OCT)/OCT angiography-based macular and peripapillary NVU parameters.</p><p><strong>Methods: </strong>This study enrolled 182 eyes with type 2 diabetes mellitus (DM) eyes and 202 healthy control eyes. The eyes of DM patients were divided into DM without DR (DM/noDR; n = 136) and DR stage groups (n = 46). Macular NVU parameters consisted of ganglion cell-inner plexiform layer (GCIPL) thickness and macular perfusion density (PD). As for peripapillary NVU parameters, peripapillary retinal nerve fiber layer (RNFL) thickness, together with radial peripapillary capillary perfusion density (RPC-PD) and RPC flux index (RPC-FI), represented by peripapillary structural and functional vascular parameters, were also examined. Macular and peripapillary parameters were compared among three stages, and correlations between macular and peripapillary parameters were examined for each stage.</p><p><strong>Results: </strong>Macular GCIPL thickness and macular PD decreased with stage progression, preserving positive correlations (i.e., preserving macular NVU) with each other in all eyes, but correlation coefficients were the lowest in DM/noDR eyes. Macular GCIPL thickness, as well as macular PD, positively correlated with peripapillary NVU parameters over the entire stages except macular PD and RNFL thickness in DR eyes (i.e., preserving macular and peripapillary NVU), but correlation coefficients were the lowest in DM/noDR eyes.</p><p><strong>Conclusions: </strong>Macular and peripapillary NVU were preserved throughout the stages: control, DM/noDR, and DR groups, but the linkage weakened at the onset of DM, suggesting diabetes-induced dysregulation of macular and peripapillary NVUs in subclinical DR.</p>","PeriodicalId":14620,"journal":{"name":"Investigative ophthalmology & visual science","volume":"66 9","pages":"10"},"PeriodicalIF":4.7000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236626/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Investigative ophthalmology & visual science","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1167/iovs.66.9.10","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Purpose: The aim of this study was to investigate the impact of diabetic retinopathy (DR) on macular and peripapillary neurovascular units (NVUs) by assessing optical coherence tomography (OCT)/OCT angiography-based macular and peripapillary NVU parameters.

Methods: This study enrolled 182 eyes with type 2 diabetes mellitus (DM) eyes and 202 healthy control eyes. The eyes of DM patients were divided into DM without DR (DM/noDR; n = 136) and DR stage groups (n = 46). Macular NVU parameters consisted of ganglion cell-inner plexiform layer (GCIPL) thickness and macular perfusion density (PD). As for peripapillary NVU parameters, peripapillary retinal nerve fiber layer (RNFL) thickness, together with radial peripapillary capillary perfusion density (RPC-PD) and RPC flux index (RPC-FI), represented by peripapillary structural and functional vascular parameters, were also examined. Macular and peripapillary parameters were compared among three stages, and correlations between macular and peripapillary parameters were examined for each stage.

Results: Macular GCIPL thickness and macular PD decreased with stage progression, preserving positive correlations (i.e., preserving macular NVU) with each other in all eyes, but correlation coefficients were the lowest in DM/noDR eyes. Macular GCIPL thickness, as well as macular PD, positively correlated with peripapillary NVU parameters over the entire stages except macular PD and RNFL thickness in DR eyes (i.e., preserving macular and peripapillary NVU), but correlation coefficients were the lowest in DM/noDR eyes.

Conclusions: Macular and peripapillary NVU were preserved throughout the stages: control, DM/noDR, and DR groups, but the linkage weakened at the onset of DM, suggesting diabetes-induced dysregulation of macular and peripapillary NVUs in subclinical DR.

糖尿病引起的乳头周围和黄斑神经血管单位的失调。
目的:本研究的目的是通过评估光学相干断层扫描(OCT)/OCT血管造影为基础的黄斑和乳头周围神经血管单位(NVU)参数,探讨糖尿病视网膜病变(DR)对黄斑和乳头周围神经血管单位(NVU)的影响。方法:选取182只2型糖尿病(DM)眼和202只健康对照眼。将DM患者的眼睛分为无DR型DM (DM/noDR;n = 136)和DR分期组(n = 46)。黄斑NVU参数包括神经节细胞-内丛状层(GCIPL)厚度和黄斑灌注密度(PD)。检测乳头周围NVU参数,同时检测乳头周围视网膜神经纤维层(RNFL)厚度,以及以乳头周围结构和功能血管参数为代表的径向乳头周围毛细血管灌注密度(RPC- pd)和RPC通量指数(RPC- fi)。比较三个阶段的黄斑和乳头周围参数,并检查每个阶段黄斑和乳头周围参数之间的相关性。结果:黄斑GCIPL厚度与黄斑PD随病程进展而降低,所有眼均保持正相关(即保持黄斑NVU),但DM/noDR眼相关系数最低。除DR眼的黄斑PD和RNFL厚度(即保留黄斑和乳头周围NVU)外,黄斑GCIPL厚度以及黄斑PD与乳头周围NVU参数在整个分期均呈正相关,但DM/noDR眼的相关系数最低。结论:在对照组、DM/noDR组和DR组中,黄斑和乳头周围NVU一直保持不变,但在DM发病时这种联系减弱,提示糖尿病诱导的亚临床DR中黄斑和乳头周围NVU失调。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
6.90
自引率
4.50%
发文量
339
审稿时长
1 months
期刊介绍: Investigative Ophthalmology & Visual Science (IOVS), published as ready online, is a peer-reviewed academic journal of the Association for Research in Vision and Ophthalmology (ARVO). IOVS features original research, mostly pertaining to clinical and laboratory ophthalmology and vision research in general.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信