Identification of proliferating neural progenitors in the adult human hippocampus

IF 44.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2025-07-03 DOI:10.1126/science.adu9575

Ionut Dumitru, Marta Paterlini, Margherita Zamboni, Christoph Ziegenhain, Sarantis Giatrellis, Rasool Saghaleyni, Åsa Björklund, Kanar Alkass, Mathew Tata, Henrik Druid, Rickard Sandberg, Jonas Frisén

引用次数: 0

Abstract

Continuous adult hippocampal neurogenesis is involved in memory formation and mood regulation but is challenging to study in humans. Difficulties finding proliferating progenitor cells called into question whether and how new neurons may be generated. We analyzed the human hippocampus from birth through adulthood by single-nucleus RNA sequencing. We identified all neural progenitor cell stages in early childhood. In adults, using antibodies against the proliferation marker Ki67 and machine learning algorithms, we found proliferating neural progenitor cells. Furthermore, transcriptomic data showed that neural progenitors were localized within the dentate gyrus. The results contribute to understanding neurogenesis in adult humans.

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成人海马中增殖神经祖细胞的鉴定

成人海马神经的持续发生与记忆形成和情绪调节有关，但对人类的研究具有挑战性。发现增殖祖细胞的困难使人们对新神经元能否产生以及如何产生产生产生了疑问。我们通过单核RNA测序分析了人类从出生到成年的海马。我们确定了儿童早期所有的神经祖细胞阶段。在成人中，使用针对增殖标记Ki67的抗体和机器学习算法，我们发现了增殖的神经祖细胞。此外，转录组学数据显示神经祖细胞位于齿状回内。这些结果有助于理解成人的神经发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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