Relationship between cerebrospinal fluid cytokines/chemokines and clinical impact of myelin oligodendrocyte glycoprotein antibody-associated disorders in children

IF 1.3 4区医学 Q4 CLINICAL NEUROLOGY

Brain & Development Pub Date : 2025-07-03 DOI:10.1016/j.braindev.2025.104389

SunMin Lee , Juhyun Kong , Sooyoung Lyu , Sang Ook Nam , Taek Jin Lim , Ji-Yeon Song , Gyu Min Yeon , Young Mi Kim , Ara Ko , Yun-Jin Lee

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Abstract

Background

Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) has been increasingly reported in children at the first presentation of an acquired central nervous system (CNS) demyelinating disorder and can have a relapsing course. This study aimed to evaluate cerebrospinal fluid (CSF) cytokine/chemokine profiles in children with acute-phase inflammatory demyelinating disorders according to MOG-IgG positivity and/or recurrent relapses.

Methods

A total of 24 cytokines/chemokines were measured using multiplex immunoassay in the CSF of 85 children, who were divided into serum MOG-IgG positive (MOG-P, n = 28) [acute disseminated encephalomyelitis (n = 19), optic neuritis (n = 8), neuromyelitis optica spectrum disorder (n = 1)] group, MOG-negative (MOGN, n = 27) demyelinating disorder group, and control (n = 30) group.

Results

All four CSF B-cell related (APRIL, BAFF, BLC/CXCL13, and MIP-3β/CCL19), Treg-related (IL-10), and the majority of CSF Th17-related (IL-6, IL-17 A, IL-21, G-CSF/CSF-3, and GM-CSF) cytokines/chemokines were significantly elevated during the acute phase in the MOG-P group compared to the MOG-N group. The mean values of B-cell-related and Treg-related (IL-10) molecules, as well as the seropositivity rate for MOG-IgG, were significantly higher in the relapse group than in the non-relapse group. Furthermore, the levels of all B-cell- and Treg-related IL-10, along with two Th17-related cytokines (IL-6, and IL-17 A), were positively correlated with the MOG-IgG titers in children with MOGAD.

Conclusion

Children with MOG-IgG positivity exhibit a pronounced CNS inflammatory response characterized by elevated levels of humoral immunity-associated cytokines/chemokines, and selected Th17-related molecules. CSF cytokine/chemokine profiles may aid in predicting relapse, monitoring inflammation and disease activity, and identifying novel therapeutic targets in pediatric MOGAD.

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脑脊液细胞因子/趋化因子与儿童髓鞘少突胶质细胞糖蛋白抗体相关疾病临床影响的关系

背景髓鞘少突胶质细胞糖蛋白（MOG）抗体相关疾病（MOGAD）在首次出现获得性中枢神经系统（CNS）脱髓鞘疾病的儿童中越来越多地报道，并且可能有复发过程。本研究旨在根据MOG-IgG阳性和/或复发评估急性期炎性脱髓鞘疾病儿童脑脊液（CSF）细胞因子/趋化因子谱。方法采用多重免疫分析法检测85例患儿脑脊液中24种细胞因子/趋化因子，将患儿分为血清MOG-IgG阳性（MOG-P, n = 28）[急性播散性脑脊髓炎（n = 19）、视神经炎（n = 8）、视神经脊髓炎谱系障碍（n = 1）]组、mog阴性（mog -n, n = 27）脱髓鞘障碍组和对照组（n = 30）。结果与MOG-N组相比，MOG-P组急性期所有4种脑脊液b细胞相关（APRIL、BAFF、BLC/CXCL13和MIP-3β/CCL19）、treg相关（IL-10）和大部分脑脊液th17相关（IL-6、IL-17 A、IL-21、G-CSF/CSF-3和GM-CSF）细胞因子/趋化因子均显著升高。复发组b细胞相关分子、treg相关分子（IL-10）均值及MOG-IgG血清阳性率均明显高于非复发组。此外，所有b细胞和treg相关的IL-10以及两种th17相关的细胞因子（IL-6和il - 17a）的水平与MOGAD患儿的MOG-IgG滴度呈正相关。结论MOG-IgG阳性的儿童表现出明显的中枢神经系统炎症反应，其特征是体液免疫相关细胞因子/趋化因子和选择性th17相关分子水平升高。脑脊液细胞因子/趋化因子谱可能有助于预测复发，监测炎症和疾病活动，并确定儿科MOGAD的新治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain & Development 医学-临床神经学

CiteScore

3.60

自引率

0.00%

发文量

153

审稿时长

50 days

期刊介绍： Brain and Development (ISSN 0387-7604) is the Official Journal of the Japanese Society of Child Neurology, and is aimed to promote clinical child neurology and developmental neuroscience. The journal is devoted to publishing Review Articles, Full Length Original Papers, Case Reports and Letters to the Editor in the field of Child Neurology and related sciences. Proceedings of meetings, and professional announcements will be published at the Editor''s discretion. Letters concerning articles published in Brain and Development and other relevant issues are also welcome.