Detecting congenital chiasmal misrouting using multichannel VEPs: protocol for a scoping review.

IF 2.6 4区医学 Q2 OPHTHALMOLOGY

Documenta Ophthalmologica Pub Date : 2025-06-28 DOI:10.1007/s10633-025-10036-z

Giulia Steuernagel Del Valle, Haipha Ali, John R Grigg, Ruth Hamilton, Michael B Hoffmann, Bruce Hudson, Wanda L Pfeifer, Dorothy A Thompson, Anupreet Tumber, Ajoy Vincent, Gerard C de Wit

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引用次数: 0

Abstract

Objective: We present the protocol of a prospective scoping review which aims to understand how multi-channel visual evoked potentials (mcVEPs) are used to investigate congenital chiasmal misrouting and what outcomes are measured, interpreted and reported.

Introduction: mcVEPs are used for the objective evaluation of chiasmal misrouting, which is characterized by a crossed asymmetry in the distribution of cortical responses over each hemisphere during monocular stimulation, and is often observed in patients with albinism. The application and analysis of mcVEPs varies across centers, creating a need to explore the range of practice regarding their conduct and reporting and to identify potential areas for adaptation or optimization or guidelines for specific populations.

Inclusion criteria: Peer reviewed and grey literature on the use of mcVEP to detect chiasmal misrouting in humans with non-acquired pathologies will be considered. All literature providing details of mcVEP methodology for replication and specification of chiasmal misrouting will be included for review.

Methods: Searches will be conducted using MEDLINE, Embase, Cochrane and Web of Science with the expertise of a librarian. The search will be conducted with no limitation on time period, but will be restricted to the Latin alphabet. Titles and abstracts will be screened by two investigators with conflicts resolved by a third investigator. Included articles will proceed with data extraction on study details including methodology, design, and outcomes. The results will be synthesized and mapped for logical understanding.

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使用多通道vep检测先天性交叉错误：范围审查方案。

目的：我们提出了一项前瞻性的综述方案，旨在了解如何使用多通道视觉诱发电位（mcVEPs）来研究先天性交叉错误，以及测量、解释和报告的结果。mcvep用于客观评价交叉错路，其特征是在单眼刺激时皮层反应在每个半球分布的交叉不对称，并且经常在白化病患者中观察到。mcvep的应用和分析因中心而异，因此需要探索其行为和报告的实践范围，并确定针对特定人群的适应或优化或指导方针的潜在领域。纳入标准：将考虑使用mcVEP检测非获得性病变患者交叉错误的同行评审和灰色文献。所有文献提供详细的mcVEP方法复制和规范交叉错路将包括审查。方法：检索将使用MEDLINE， Embase， Cochrane和Web of Science与图书馆员的专业知识。搜索将不受时间限制，但将限于拉丁字母。标题和摘要将由两名研究者筛选，冲突由第三名研究者解决。纳入的文章将继续对研究细节进行数据提取，包括方法、设计和结果。将对结果进行综合和映射，以便进行逻辑理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Documenta Ophthalmologica 医学-眼科学

CiteScore

3.50

自引率

21.40%

发文量

审稿时长

>12 weeks

期刊介绍： Documenta Ophthalmologica is an official publication of the International Society for Clinical Electrophysiology of Vision. The purpose of the journal is to promote the understanding and application of clinical electrophysiology of vision. Documenta Ophthalmologica will publish reviews, research articles, technical notes, brief reports and case studies which inform the readers about basic and clinical sciences related to visual electrodiagnosis and means to improve diagnosis and clinical management of patients using visual electrophysiology. Studies may involve animals or humans. In either case appropriate care must be taken to follow the Declaration of Helsinki for human subject or appropriate humane standards of animal care (e.g., the ARVO standards on Animal Care and Use).