Dual SERS-enhanced core-shell-satellite assemblies with Cu-doped ZIF-8 interlayer for OTA detection

IF 9.8 1区农林科学 Q1 CHEMISTRY, APPLIED

Food Chemistry Pub Date : 2025-06-27 DOI:10.1016/j.foodchem.2025.145340

Ying Yang , Wenqi Zhang , Lu Zhang , Ziyan Shi , Dexiang Wei , Weiwei Xia , Xiaoguang Xu

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Abstract

Ochratoxin A (OTA) is a highly toxic and bioaccumulative mycotoxin found in grains, threatening food safety. Surface-enhanced Raman spectroscopy (SERS) combined with immunochromatography enables rapid and sensitive detection of OTA. This study aimed to develop a novel core-shell-satellite SERS probe (Au@Ag@(Cu-ZIF-8)-AuNPs) for OTA detection. The structure comprised an Au@Ag nanoparticle core, coated with Cu-doped ZIF-8 and gold nanosatellites. This design generated dense electromagnetic “hot spots” through plasmonic coupling between the core and satellites. Simultaneously, Cu doping reduced the bandgap of ZIF-8, thus enhancing charge transfer efficiency for chemical signal amplification. The dual electromagnetic-chemical enhancement achieved a detection range of 0.1 fg/mL–1.0 μg/mL and an ultralow detection limit of 0.057 fg/mL, thereby surpassing the detection limits of conventional methods. This innovative probe, with its high sensitivity and wide dynamic range, offers a powerful platform for mycotoxin monitoring, hence advancing SERS-based rapid detection technologies crucial for food safety.

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带有cu掺杂ZIF-8中间层的双sers增强核-壳-卫星组件用于OTA检测

赭曲霉毒素A （Ochratoxin A， OTA）是一种在谷物中发现的剧毒和生物蓄积性真菌毒素，威胁着食品安全。表面增强拉曼光谱（SERS）与免疫层析相结合，可以快速、灵敏地检测OTA。本研究旨在开发一种用于OTA检测的新型核-壳-卫星SERS探针（Au@Ag@(Cu-ZIF-8)-AuNPs）。该结构由Au@Ag纳米粒子核心组成，涂有掺杂cu的ZIF-8和金纳米卫星。这种设计通过核心和卫星之间的等离子体耦合产生了密集的电磁“热点”。同时，Cu掺杂减小了ZIF-8的带隙，从而提高了化学信号放大的电荷转移效率。双电磁-化学增强的检测范围为0.1 fg/mL ~ 1.0 μg/mL，超低检出限为0.057 fg/mL，超过了常规方法的检出限。这种创新的探针具有高灵敏度和宽动态范围，为霉菌毒素监测提供了一个强大的平台，从而推进了对食品安全至关重要的基于sers的快速检测技术。

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来源期刊

Food Chemistry 工程技术-食品科技

CiteScore

16.30

自引率

10.20%

发文量

3130

审稿时长

122 days

期刊介绍： Food Chemistry publishes original research papers dealing with the advancement of the chemistry and biochemistry of foods or the analytical methods/ approach used. All papers should focus on the novelty of the research carried out.