Neuro-modulatory targets of aggression, depression and suicidal behaviour

Abstract

Exposomes have a significant influence on an individual’s life as they are encounter with various exposomes throughout their lifetime. While some are evident, others may remain unnoticed. A systematic examination of relevant biomarkers can be beneficial in understanding the role of exposomes associated with neuropsychological disorders. Most of the neuropsychological conditions, including depression, aggression and suicidal tendencies, are commonly prevalent worldwide. Numerous studies have been carried out regarding neurobiological markers and their pivotal role in managing these situations. However, very limited information is available regarding the correlation of these neurobehavioral abnormalities with the neurochemical and molecular alterations. Given the neuropsychological health risk, this review aimed to provide a holistic approach to exploring the involvement of several neuro-modulatory targets including neurotransmitters, inflammatory cytokines, neuro-endocrinal, molecular and genetic markers and their association with neuropsychological disorders. A thorough literature search was carried out in this direction, and relevant articles were retrieved and included in the present review. The present review unravels the interplay of exposomes in altering the neuro-modulatory targets and their linkage with neuropsychological disorders for better understanding of human behaviour and specific approach for their treatment.