Effect of parental perinatal exposure to L-glutamate monosodium salt monohydrate on developmental neurotoxicity in rat offspring

Abstract

This study aimed to provide preliminary information about the potential adverse effects of L-Glutamate Monosodium Salt Monohydrate on maternal health and offspring development, particularly about developmental neurotoxicity and abnormal behavior in offspring after oral administration by gavage to female SD rats during the perinatal stage. The study involved administering different doses of L-glutamate monosodium salt monohydrate to four groups, including a vehicle control group. The doses were given orally via gavage from gestation day 6 (GD6) until postnatal day 21 (PND21) at levels of 6000, 3000, and 1000 mg/kg BW. The study found that parental exposure to L-Glutamate Monosodium Salt Monohydrate at a dose of 6000 mg/kg BW had adverse effects on the growth and development of the offspring. These effects included delayed physical development and reflex development. However, no effects on dams were observed. The Lowest Observed Adverse Effect Level (LOAEL) for developmental toxicity to the offspring is 6000 mg/kg BW, and the No Observed Adverse Effect Level (NOAEL) is 3000 mg/kg BW. Additionally, the NOAEL for maternal toxicity is considered to be 6000 mg/kg BW.