Sleep spindle abnormalities as neurophysiological biomarkers of Schizophrenia spectrum disorders: From cellular mechanisms and neural circuits to clinical implications

IF 9.6 1区医学 Q1 NEUROSCIENCES

Biological Psychiatry Pub Date : 2025-06-25 DOI:10.1016/j.biopsych.2025.06.014

Anna Castelnovo, Armando D’Agostino, Ahmad Mayeli, Larissa Albantakis, Giulio Tononi, Fabio Ferrarelli

引用次数: 0

Abstract

Although not included in current diagnostic criteria, sleep disturbances are common in patients with schizophrenia (SCZ) and significantly impact their cognitive function and clinical outcomes. Among sleep disturbances, abnormalities in sleep spindles—non-rapid eye movement (NREM) thalamocortical oscillations essential for sleep stability and memory consolidation—have emerged as potential neurophysiological biomarkers of SCZ.

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睡眠纺锤体异常作为精神分裂症谱系障碍的神经生理生物标志物：从细胞机制和神经回路到临床意义

虽然不包括在目前的诊断标准，睡眠障碍是常见的精神分裂症患者（SCZ）和显著影响他们的认知功能和临床结果。在睡眠障碍中，睡眠纺锤波异常——非快速眼动（NREM）丘脑皮质振荡对睡眠稳定和记忆巩固至关重要——已成为SCZ潜在的神经生理生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biological Psychiatry 医学-精神病学

CiteScore

18.80

自引率

2.80%

发文量

1398

审稿时长

33 days

期刊介绍： Biological Psychiatry is an official journal of the Society of Biological Psychiatry and was established in 1969. It is the first journal in the Biological Psychiatry family, which also includes Biological Psychiatry: Cognitive Neuroscience and Neuroimaging and Biological Psychiatry: Global Open Science. The Society's main goal is to promote excellence in scientific research and education in the fields related to the nature, causes, mechanisms, and treatments of disorders pertaining to thought, emotion, and behavior. To fulfill this mission, Biological Psychiatry publishes peer-reviewed, rapid-publication articles that present new findings from original basic, translational, and clinical mechanistic research, ultimately advancing our understanding of psychiatric disorders and their treatment. The journal also encourages the submission of reviews and commentaries on current research and topics of interest.