Cognitive interference elicits developmental sex differences in inhibitory control

IF 4.9 2区医学 Q1 NEUROSCIENCES

Developmental Cognitive Neuroscience Pub Date : 2025-06-25 DOI:10.1016/j.dcn.2025.101590

Jake J. Son , Abraham D. Killanin , Mikki Schantell , Yasra Arif , Thomas W. Ward , Maggie P. Rempe , Grace C. Ende , Hannah J. Okelberry , Danielle L. Rice , Anna T. Coutant , Julia M. Stephen , Yu-Ping Wang , Vince D. Calhoun , Alex I. Wiesman , Tony W. Wilson

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Abstract

Inhibitory control is a key component of cognitive control that enables children and adolescents to develop increasingly complex skills throughout development. These processes are subject to insult via endogenous and environmental stressors (e.g., puberty, trauma) and alterations can lead to significant behavioral impairments that persist into adulthood. Despite this, the normative developmental course of neural oscillatory activity underlying interference control, a critical subcomponent of inhibitory control, and potential sex differences along this course, remain poorly understood. Herein, we utilized high-density magnetoencephalography (MEG) during the Eriksen flanker task to map the developmental sensitivity of neural processes supporting interference control in a large sample of children and adolescents (N = 121). MEG data were transformed into the time-frequency domain and significant oscillatory responses were imaged using a beamformer. Whole-brain analysis of flanker interference maps (i.e., incongruent - congruent trials) revealed age-related decreases in theta power in the supplementary motor area and cerebellum. Furthermore, regions known to be critical for supporting cognitive control, including the prefrontal and parietal cortices, exhibited age-by-sex interactive effects, suggesting modulation of interference control throughout development in a sex-dependent manner. Taken together, these data contribute to the characterization of the electrophysiological mechanisms supporting the development and refinement of interference control.

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认知干扰引起抑制控制的发育性别差异

抑制性控制是认知控制的一个关键组成部分，它使儿童和青少年在整个发展过程中发展出越来越复杂的技能。这些过程会受到内源性和环境压力因素（例如，青春期、创伤）的影响，而这些改变会导致持续到成年的重大行为障碍。尽管如此，作为抑制控制的一个重要组成部分，干扰控制下的神经振荡活动的规范发育过程，以及这一过程中潜在的性别差异，仍然知之甚少。在此，我们在埃里克森侧侧任务中使用高密度脑磁图（MEG）来绘制支持干扰控制的神经过程在儿童和青少年中的发育敏感性（N = 121）。MEG数据被转换成时频域，并使用波束形成器对显著的振荡响应进行成像。侧侧干扰图的全脑分析（即，不一致-一致试验）显示辅助运动区和小脑的θ波功率与年龄相关。此外，已知对支持认知控制至关重要的区域，包括前额叶和顶叶皮层，显示出年龄与性别的相互作用，表明在整个发育过程中，干扰控制以性别依赖的方式进行调节。综上所述，这些数据有助于表征支持干扰控制发展和完善的电生理机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Developmental Cognitive Neuroscience NEUROSCIENCES-

CiteScore

7.60

自引率

10.60%

发文量

124

审稿时长

6-12 weeks

期刊介绍： The journal publishes theoretical and research papers on cognitive brain development, from infancy through childhood and adolescence and into adulthood. It covers neurocognitive development and neurocognitive processing in both typical and atypical development, including social and affective aspects. Appropriate methodologies for the journal include, but are not limited to, functional neuroimaging (fMRI and MEG), electrophysiology (EEG and ERP), NIRS and transcranial magnetic stimulation, as well as other basic neuroscience approaches using cellular and animal models that directly address cognitive brain development, patient studies, case studies, post-mortem studies and pharmacological studies.