Serum 3-Nitrotyrosine in the Cardiovascular Disease of Patients with Systemic Lupus Erythematosus.

IF 6 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Juan C Quevedo-Abeledo, Marta Hernández-Díaz, María García-González, Fuensanta Gómez-Bernal, Cristina Almeida-Santiago, Elena Heras-Recuero, Antonia de Vera-González, Alejandra González-Delgado, Pedro Abreu-González, Beatriz Tejera-Segura, Candelaria Martín-González, Miguel Á González-Gay, Iván Ferraz-Amaro
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引用次数: 0

Abstract

3-Nitrotyrosine (3-NT) is a product of tyrosine nitration mediated by reactive nitrogen species such as peroxynitrite anion and nitrogen dioxide. It serves as an indicator of inflammation, cell damage, and nitric oxide production. Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by multisystem involvement and increased oxidative stress. Notably, cardiovascular (CV) disease has emerged as the leading cause of mortality among SLE patients. Our objective was to investigate the association between serum 3-NT levels and a wide range of disease characteristics in patients with SLE, with a particular emphasis on CV comorbidity. A total of 214 patients with SLE were enrolled. The serum levels of 3-NT as well as the activity (SLEDAI) and damage index (SLICC-SDI) scores, full lipid profile, insulin resistance indices, and carotid subclinical atherosclerosis were assessed. Multivariable linear regression analysis was carried out to study the relationship between 3-NT and clinical and laboratory disease characteristics, especially focusing on CV comorbidities. Except for body mass index, which showed a significant positive correlation, the demographic data and traditional CV risk factors did not correlate with 3-NT. After multivariable adjustments, several disease characteristics, including the disease duration, activity and damage indices, and autoantibody profile, showed significant positive associations with 3-NT. Regarding CV characteristics, several lipid profile molecules showed significant relationships with 3-NT. This was not the case for insulin resistance and subclinical atherosclerosis. Remarkably, patients with a high CV risk by SCORE2 showed higher 3-NT values compared to those with a low risk, although after the multivariable adjustment, this relationship was attenuated (but still showed a trend). In conclusion, serum 3-NT levels demonstrated significant positive correlations with multiple disease characteristics, including the disease activity and damage and the autoantibody profile. The lipid pattern in the SLE subjects also significantly and independently correlated with the 3-NT values. Our findings highlight the pathophysiological role of 3-NT specifically, and peroxidation in general, in patients with SLE.

血清3-硝基酪氨酸与系统性红斑狼疮患者心血管疾病的关系。
3-硝基酪氨酸(3-NT)是酪氨酸在过氧亚硝酸盐阴离子和二氧化氮等活性氮物质介导下硝化的产物。它可以作为炎症、细胞损伤和一氧化氮生成的指标。系统性红斑狼疮(SLE)是一种以多系统参与和氧化应激增加为特征的自身免疫性疾病。值得注意的是,心血管(CV)疾病已成为SLE患者死亡的主要原因。我们的目的是研究血清3-NT水平与SLE患者广泛疾病特征之间的关系,特别强调心血管合并症。共有214例SLE患者入组。评估血清3-NT水平、活性(SLEDAI)和损伤指数(SLICC-SDI)评分、全脂质谱、胰岛素抵抗指数和颈动脉亚临床动脉粥样硬化。采用多变量线性回归分析研究3-NT与临床和实验室疾病特征的关系,尤其关注CV合并症。除体质指数与3-NT呈显著正相关外,人口统计学资料和传统的CV危险因素与3-NT无相关性。在多变量调整后,一些疾病特征,包括疾病持续时间、活动性和损伤指数以及自身抗体谱,显示出与3-NT显著正相关。在CV特征方面,一些脂质分子与3-NT有显著关系。而胰岛素抵抗和亚临床动脉粥样硬化则不是这样。值得注意的是,经SCORE2评估的高CV风险患者的3-NT值高于低CV风险患者,尽管经过多变量调整后,这种关系有所减弱(但仍呈趋势)。总之,血清3-NT水平与多种疾病特征呈显著正相关,包括疾病活动性和损害以及自身抗体谱。SLE患者的脂质模式也与3-NT值显著且独立相关。我们的研究结果强调了3-NT在SLE患者中的病理生理作用,以及一般的过氧化作用。
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来源期刊
Antioxidants
Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology
CiteScore
10.60
自引率
11.40%
发文量
2123
审稿时长
16.3 days
期刊介绍: Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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