Puerarin as a Phytochemical Modulator of Gastrointestinal Homeostasis in Livestock: Molecular Mechanisms and Translational Applications.

IF 6 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Jiehong Zhou, Jianyu Lv, Xin Chen, Tian Li, Jianzhong Shen, Zhanhui Wang, Chongshan Dai, Zhihui Hao
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引用次数: 0

Abstract

The gut serves as the main site for nutrient digestion and absorption. Simultaneously, it functions as the body's largest immune organ, playing a dual role in sustaining physiological equilibrium and offering immunological defense against intestinal ailments. Maintaining the structural and functional integrity of the intestine is paramount for ensuring animal health and productivity. Puerarin, a naturally derived isoflavonoid from the Pueraria species, exhibits multifaceted bioactivities, such as antioxidant, anti-inflammatory, antimicrobial, and immunomodulatory properties. Emerging evidence highlights puerarin's capacity to enhance gut health in farm animals through four pivotal mechanisms: (1) optimization of intestinal morphology via crypt-villus architecture remodeling, (2) augmentation of systemic and mucosal antioxidant defenses through Nrf2/ARE pathway activation, and (3) reinforcement of intestinal barrier function by regulating tight junction proteins (e.g., ZO-1, occludin), mucin secretion, intestinal mucosal immune barrier, the composition of microbiota, and the derived beneficial metabolites; (4) regulating the function of the intestinal nervous system via reshaping the distribution of intestinal neurons and neurotransmitter secretion function. This review synthesizes current knowledge on puerarin's protective effects on intestinal physiology in farm animals, systematically elucidates its underlying molecular targets (including TLR4/NF-κB, MAPK, and PI3K/Akt signaling pathways), and critically evaluates its translational potential in mitigating enteric disorders such as post-weaning diarrhea and inflammatory bowel disease in agricultural practices.

葛根素作为家畜胃肠稳态的植物化学调节剂:分子机制和转化应用。
肠道是营养物质消化和吸收的主要部位。同时,它作为人体最大的免疫器官,在维持生理平衡和对肠道疾病提供免疫防御方面发挥双重作用。维持肠道结构和功能的完整性对确保动物健康和生产力至关重要。葛根素是一种从葛根属植物中天然提取的异黄酮,具有多方面的生物活性,如抗氧化、抗炎、抗菌和免疫调节特性。新出现的证据表明,葛根素能够通过四个关键机制增强农场动物的肠道健康:(1)通过隐窝绒毛结构重塑优化肠道形态;(2)通过激活Nrf2/ARE通路增强全身和粘膜抗氧化防御;(3)通过调节紧密连接蛋白(如ZO-1、occludin)、粘蛋白分泌、肠黏膜免疫屏障、微生物群组成和衍生的有益代谢物来增强肠道屏障功能;(4)通过重塑肠道神经元分布和神经递质分泌功能来调节肠道神经系统功能。本综述综合了目前关于葛根素对农场动物肠道生理保护作用的知识,系统地阐明了其潜在的分子靶点(包括TLR4/NF-κB、MAPK和PI3K/Akt信号通路),并批判性地评估了其在缓解农业实践中断奶后腹泻和炎症性肠病等肠道疾病的转化潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Antioxidants
Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology
CiteScore
10.60
自引率
11.40%
发文量
2123
审稿时长
16.3 days
期刊介绍: Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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