The Impact of the Skin Microbiome and Oxidative Stress on the Initiation and Development of Cutaneous Chronic Wounds.

IF 6 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Manuela Martins-Green, Jane Kim, Klara Aziz
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引用次数: 0

Abstract

Wound healing is a very complex process composed of several phases in which precise events occur, both temporally and specially. However, when these processes go awry, biofilm-forming bacteria become installed in the healing tissue, and the patient has comorbidities, so the wounds do not heal and become chronic. In this review, we describe the importance of high levels of oxidative stress (OS) and bacteria from the skin microbiome in the initiation and development of chronic wounds. The skin microbiome is diverse in humans, and its composition is dependent on the environment in the specific areas of the body. OS is critical for wound healing as it stimulates the immune system to destroy pathogens and secrete cytokines and growth factors that stimulate healing. When OS levels become high in the wound and the bacteria of the skin install themselves in the wound, chronicity ensues. However, neither OS nor the bacteria of the skin alone can initiate chronicity. However, when present together, chronic wounds develop. Given the complexity of chronic wound initiation, developing treatment for these wounds has been difficult. Here, we also discuss the challenges of treating chronic wounds and offer a potential sequence of approaches to treating these wounds after debridement.

皮肤微生物组和氧化应激对皮肤慢性伤口发生和发展的影响。
伤口愈合是一个非常复杂的过程,由几个阶段组成,其中发生了精确的事件,既有时间上的,也有特殊的。然而,当这些过程出错时,形成生物膜的细菌就会安装在愈合的组织中,患者就会出现合并症,因此伤口无法愈合而成为慢性疾病。在这篇综述中,我们描述了高水平的氧化应激(OS)和来自皮肤微生物组的细菌在慢性伤口的发生和发展中的重要性。人体皮肤微生物群是多种多样的,其组成取决于身体特定区域的环境。OS对伤口愈合至关重要,因为它刺激免疫系统破坏病原体,分泌细胞因子和生长因子,促进愈合。当伤口中的OS水平升高时,皮肤上的细菌就会进入伤口,慢性疾病就会随之而来。然而,OS和皮肤上的细菌都不能单独引发慢性疾病。然而,如果一起出现,就会形成慢性伤口。鉴于慢性伤口形成的复杂性,开发这些伤口的治疗方法一直很困难。在这里,我们还讨论了治疗慢性伤口的挑战,并提供了清创后治疗这些伤口的潜在方法序列。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Antioxidants
Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology
CiteScore
10.60
自引率
11.40%
发文量
2123
审稿时长
16.3 days
期刊介绍: Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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