The Current Landscape of Phage-Antibiotic Synergistic (PAS) Interactions.

IF 4.3 2区 医学 Q1 INFECTIOUS DISEASES
Brittany S I Supina, Jonathan J Dennis
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引用次数: 0

Abstract

Background: In response to the urgent need for new antibiotics targeting high-priority MDR pathogens, bacteriophages (phages) have emerged as promising non-traditional antimicrobial agents. Phages are viruses that infect bacteria and induce cell lysis through mechanisms distinct from those of antibiotics, making them largely unaffected by most antibiotic resistance mechanisms. Importantly, phages have been shown to work cooperatively with an array of clinically useful antibiotics, and phage-antibiotic synergy (PAS) represents a sophisticated strategy that may improve treatment outcomes. However, the interactions between phages and antibiotics are diverse, ranging from synergistic to antagonistic, and understanding the mechanisms underlying these interactions is crucial for developing effective PAS treatments. In this review, we summarize the potential evolutionary and molecular mechanisms that drive PAS and the current landscape of phage-antibiotic interactions. Conclusions: Towards the development of robust PAS strategies, we review in vitro methods for assessing PAS and considerations for choosing and employing candidate phage-antibiotic combinations.

噬菌体-抗生素协同(PAS)相互作用的现状。
背景:为了应对针对高度优先的耐多药病原体的新型抗生素的迫切需求,噬菌体(噬菌体)已成为有前途的非传统抗菌药物。噬菌体是一种感染细菌并通过与抗生素不同的机制诱导细胞裂解的病毒,这使得它们在很大程度上不受大多数抗生素耐药机制的影响。重要的是,噬菌体已被证明与一系列临床有用的抗生素合作,噬菌体-抗生素协同作用(PAS)代表了一种可能改善治疗结果的复杂策略。然而,噬菌体与抗生素之间的相互作用是多种多样的,从协同作用到拮抗作用,了解这些相互作用的机制对于开发有效的PAS治疗至关重要。在这篇综述中,我们总结了驱动PAS的潜在进化和分子机制以及噬菌体-抗生素相互作用的现状。结论:为了开发强大的PAS策略,我们回顾了体外评估PAS的方法以及选择和使用候选噬菌体-抗生素组合的考虑因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Antibiotics-Basel
Antibiotics-Basel Pharmacology, Toxicology and Pharmaceutics-General Pharmacology, Toxicology and Pharmaceutics
CiteScore
7.30
自引率
14.60%
发文量
1547
审稿时长
11 weeks
期刊介绍: Antibiotics (ISSN 2079-6382) is an open access, peer reviewed journal on all aspects of antibiotics. Antibiotics is a multi-disciplinary journal encompassing the general fields of biochemistry, chemistry, genetics, microbiology and pharmacology. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of papers.
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