Candidozyma auris Outbreak and Its Effective Control in a General Hospital.

IF 4.3 2区 医学 Q1 INFECTIOUS DISEASES
Flora V Kontopidou, Maria Antonopoulou, Anastasia Votsi, Vassiliki Papoutsaki, Vassiliki Bereri, Evangelia Kourkoulou, Amalia Rompola, Georgia Tsokou, Anna Pavli, Olga Maria Koutantelia, Maria Siopi, Sevasti Leventaki, Joseph Meletiadis, George L Daikos
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Abstract

Background/Objectives:Candidozyma auris (C. auris) is a multidrug-resistant pathogen recognized as a serious global public health threat. Herein, we report a C. auris outbreak that was successfully contained in a general hospital located in Athens, Greece. Methods: This study was conducted between December 2021 and December 2023. Upon identification of the first imported case of C. auris, the following infection control measures were applied in a stepwise approach: the promotion of hand hygiene, contact precautions and isolation, chlorhexidine gluconate bathing of patients, enhanced environmental cleaning, and active surveillance cultures of all high-risk patients upon admission. Active surveillance cultures were performed weekly in non-colonized ICU patients. Results: A total of 1564 screening samples from 890 patients were analyzed. Sixty-three patients were identified to be colonized and three to be infected with C. auris. After implementing screening and enhanced environmental cleaning, the quarterly incidence of hospital-acquired cases decreased from 0.37 to 0.04 cases per 1000 patient-days (slope of linear trend: -0.08; 95% CI: -0.16 to -0.0004; p = 0.05), despite the continuous inflow of already colonized patients. Conclusions: A bundle of infection control measures, including active surveillance cultures upon admission and enhanced environmental cleaning, can contain C. auris dissemination in acute healthcare settings.

某综合医院耳念珠菌暴发及有效控制
背景/目的:耳念珠菌(C. auris)是一种多重耐药病原体,被认为是严重的全球公共卫生威胁。在此,我们报告了在希腊雅典的一家综合医院成功控制的金黄色葡萄球菌暴发。方法:本研究于2021年12月至2023年12月进行。在发现首例输入性金黄色葡萄球菌病例后,采取了以下感染控制措施:促进手部卫生、接触预防和隔离、患者使用葡萄糖酸氯己定沐浴、加强环境清洁,并在所有高危患者入院时对其进行积极监测培养。非定植ICU患者每周进行主动监测培养。结果:共分析890例患者的1564份筛查样本。63例患者被确定为定植菌,3例被确定为金黄色葡萄球菌感染。在实施筛查和加强环境清洁后,医院获得性病例的季度发病率从每1000患者日0.37例降至0.04例(线性趋势斜率:-0.08;95% CI: -0.16 ~ -0.0004;P = 0.05),尽管已经定植的患者不断流入。结论:一系列感染控制措施,包括入院时的主动监测培养和加强环境清洁,可在急性医疗机构中控制耳球菌的传播。
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来源期刊
Antibiotics-Basel
Antibiotics-Basel Pharmacology, Toxicology and Pharmaceutics-General Pharmacology, Toxicology and Pharmaceutics
CiteScore
7.30
自引率
14.60%
发文量
1547
审稿时长
11 weeks
期刊介绍: Antibiotics (ISSN 2079-6382) is an open access, peer reviewed journal on all aspects of antibiotics. Antibiotics is a multi-disciplinary journal encompassing the general fields of biochemistry, chemistry, genetics, microbiology and pharmacology. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of papers.
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