{"title":"Hypervirulent <i>Acinetobacter baumannii</i> (hvAB): The Convergence of Virulence and Multidrug Resistance.","authors":"Nan Wu, Xinqian Ma, Wentao Ni","doi":"10.3390/antibiotics14060551","DOIUrl":null,"url":null,"abstract":"<p><p><i>Acinetobacter baumannii</i> has become a formidable pathogen in healthcare systems worldwide, primarily due to its remarkable capacity to develop multidrug resistance and cause life-threatening infections. While traditionally <i>A. baumannii</i> is considered an opportunistic pathogen of low virulence, accumulating evidence now underscores the emergence of hypervirulent <i>A. baumannii</i> (hvAB) strains. These strains combine heightened pathogenicity with extensive drug resistance, posing unprecedented challenges for clinical management and infection containment. This review comprehensively explores the molecular mechanisms driving hvAB's virulence and antimicrobial resistance and its evolutionary trajectory, clinical presentations, and global epidemiology. Additionally, we evaluate potential therapeutic strategies and their broader public health implications.</p>","PeriodicalId":54246,"journal":{"name":"Antibiotics-Basel","volume":"14 6","pages":""},"PeriodicalIF":4.3000,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12190087/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Antibiotics-Basel","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/antibiotics14060551","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
Abstract
Acinetobacter baumannii has become a formidable pathogen in healthcare systems worldwide, primarily due to its remarkable capacity to develop multidrug resistance and cause life-threatening infections. While traditionally A. baumannii is considered an opportunistic pathogen of low virulence, accumulating evidence now underscores the emergence of hypervirulent A. baumannii (hvAB) strains. These strains combine heightened pathogenicity with extensive drug resistance, posing unprecedented challenges for clinical management and infection containment. This review comprehensively explores the molecular mechanisms driving hvAB's virulence and antimicrobial resistance and its evolutionary trajectory, clinical presentations, and global epidemiology. Additionally, we evaluate potential therapeutic strategies and their broader public health implications.
Antibiotics-BaselPharmacology, Toxicology and Pharmaceutics-General Pharmacology, Toxicology and Pharmaceutics
CiteScore
7.30
自引率
14.60%
发文量
1547
审稿时长
11 weeks
期刊介绍：
Antibiotics (ISSN 2079-6382) is an open access, peer reviewed journal on all aspects of antibiotics. Antibiotics is a multi-disciplinary journal encompassing the general fields of biochemistry, chemistry, genetics, microbiology and pharmacology. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of papers.
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