Recent Insights About Probiotics Related Pharmabiotics in Pharmacology: Prevention and Management of Diseases.

IF 4.4 2区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Sena Davran Bulut, H Ali Döndaş, Hasan Ufuk Celebioglu, José M Sansano, Naciye Yaktubay Döndaş
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引用次数: 0

Abstract

The science of pharmacology investigates the effects of drugs on living organisms and vice versa. The frequency of side effects of some drugs used in traditional pharmacological treatment approaches and/or their inability to provide adequate treatment has led to the importance of new drug research and development (R&D) studies. Recently, due to the discovery that some diseases are associated with an imbalanced microbiota (dysbiosis), there has been a surge of interest in therapeutic approaches that can restore balance (biosis) to the microbiota. This review discusses the current status of the pharmabiotic potential of probiotics, prebiotics, synbiotics, paraprobiotics, postbiotics, metabiotics, next-generation probiotics, and fecal microbiota transplantation; describes their pharmacological functions from gastrointestinal disorders to neurodegenerative diseases; and also discusses the developments in pharmaceutical applications of probiotics and their derivatives.

药理学中与益生菌相关的药物研究进展:疾病的预防和管理。
药理学研究药物对生物体的作用,反之亦然。传统药理学治疗方法中使用的一些药物的副作用频率和/或它们无法提供充分的治疗,导致了新药研究和开发(R&D)研究的重要性。最近,由于发现一些疾病与微生物群失衡(生态失调)有关,人们对恢复微生物群平衡(生态失调)的治疗方法产生了浓厚的兴趣。本文综述了益生菌、益生元、合成菌、副益生菌、后益生菌、代谢菌、新一代益生菌和粪便菌群移植的药理潜力现状;描述了它们从胃肠道疾病到神经退行性疾病的药理作用;并讨论了益生菌及其衍生物在制药方面的应用进展。
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来源期刊
Probiotics and Antimicrobial Proteins
Probiotics and Antimicrobial Proteins BIOTECHNOLOGY & APPLIED MICROBIOLOGYMICROB-MICROBIOLOGY
CiteScore
11.30
自引率
6.10%
发文量
140
期刊介绍: Probiotics and Antimicrobial Proteins publishes reviews, original articles, letters and short notes and technical/methodological communications aimed at advancing fundamental knowledge and exploration of the applications of probiotics, natural antimicrobial proteins and their derivatives in biomedical, agricultural, veterinary, food, and cosmetic products. The Journal welcomes fundamental research articles and reports on applications of these microorganisms and substances, and encourages structural studies and studies that correlate the structure and functional properties of antimicrobial proteins.
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