Does the Association Between Eye Disease and Cognitive Function Vary by Genetic Risk of Cognitive Decline? An Analysis of Hospital Data With Replication in the Canadian Longitudinal Study on Aging.

IF 5 2区医学 Q1 OPHTHALMOLOGY

Investigative ophthalmology & visual science Pub Date : 2025-06-02 DOI:10.1167/iovs.66.6.71

Emily Tran, Mohan Rakesh, Gisele Li, Ellen E Freeman, Marie-Hélène Roy-Gagnon

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引用次数: 0

Abstract

Purpose: Age-related eye diseases are inconsistently associated with cognitive decline which could be due to effect modification. The purpose of this study was to investigate whether two genetic factors previously found to be associated with cognitive decline, the KIBRA (WWC1) and PDE7A/MTFR1 genes, modify the association between eye disease and cognitive function.

Methods: Data from a Montreal hospital-based cross-sectional study (n = 302) were used for the primary analysis. Candidate single-nucleotide polymorphisms (SNPs) rs17070145 (KIBRA gene) and rs10808746 (PDE7A/MTFR1 gene) were included in linear regression models to test for effect modification of the relationship between eye disease (glaucoma or age-related macular degeneration [AMD]) and cognitive function. Six oral cognitive tests were used. A replication analysis was done using the Quebec data from the Canadian Longitudinal Study on Aging (CLSA) (n = 4238). Effect modifications by expanded genomic regions around the candidate SNPs were tested.

Results: Three statistically significant interactions with two cognitive function measures -category verbal fluency and immediate story recall-were found in the Montreal study: glaucoma and AMD with rs17070145 and verbal fluency (P < 0.03) and glaucoma with rs10808746 with immediate story recall (P < 0.05). Similar interactions, although not with the same cognitive measure, were found in the CLSA: AMD with KIBRA and glaucoma with PDE7A/MTFR1.

Conclusions: Our results suggest that the KIBRA and PDE7A/MTFR1 genes may modify the association between eye disease and cognitive function. This knowledge may help to better understand the mechanism by which glaucoma and AMD are related to cognitive function.

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眼病与认知功能之间的关系是否因认知能力下降的遗传风险而异？加拿大老龄化纵向研究中具有重复性的医院数据分析

目的：与年龄相关的眼病与认知能力下降的关系并不一致，这可能是由于效果的改变。本研究的目的是调查两个先前发现的与认知能力下降相关的遗传因素，KIBRA （WWC1）和PDE7A/MTFR1基因，是否改变了眼病和认知功能之间的关系。方法：来自蒙特利尔医院横断面研究的数据（n = 302）用于初步分析。将候选单核苷酸多态性（snp） rs17070145 （KIBRA基因）和rs10808746 （PDE7A/MTFR1基因）纳入线性回归模型，以检验眼病（青光眼或年龄相关性黄斑变性[AMD]）与认知功能之间关系的效应修饰。使用了六项口头认知测试。使用来自加拿大老龄化纵向研究（CLSA）的魁北克数据（n = 4238）进行了重复分析。通过扩展候选snp周围的基因组区域，测试了效应修饰。结果：在蒙特利尔研究中，两项认知功能测量-类别语言流畅性和即时故事回忆-发现了三个具有统计学意义的相互作用：青光眼和AMD的rs17070145和语言流畅性（P < 0.03），青光眼的rs10808746与即时故事回忆（P < 0.05）。类似的相互作用，虽然不是相同的认知测量，在里昂证券：AMD合并KIBRA和青光眼合并PDE7A/MTFR1中被发现。结论：我们的研究结果表明，KIBRA和PDE7A/MTFR1基因可能改变了眼病与认知功能之间的关系。这一知识可能有助于更好地理解青光眼和AMD与认知功能相关的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Investigative ophthalmology & visual science 医学-眼科学

CiteScore

6.90

自引率

4.50%

发文量

339

审稿时长

1 months

期刊介绍： Investigative Ophthalmology & Visual Science (IOVS), published as ready online, is a peer-reviewed academic journal of the Association for Research in Vision and Ophthalmology (ARVO). IOVS features original research, mostly pertaining to clinical and laboratory ophthalmology and vision research in general.