An Updated Review Deciphering the Inhibitory Potential of Erianin via Targeting Several Dysregulated Oncogenes in Several Human Carcinomas.

IF 2.8 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current pharmaceutical design Pub Date : 2025-06-18 DOI:10.2174/0113816128372087250528163929

Pratibha Pandey, Seema Ramniwas, Lalji Baldaniya, G PadmaPriya, Khushboo Rani, Shivang Mishra, Irwanjot Kaur, Shivam Pandey, Sorabh Lakhanpal, Fahad Khan

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引用次数: 0

Abstract

Numerous edible vegetables and fruits possess plant-based compounds with enormous anticarcinogenic attributes, including phenolic, vitamins, and alkaloid compounds. Cancer therapies mainly encompass surgery, chemotherapy, and radiation therapy, sometimes accompanied by rapid recurrence and significant side effects. Consequently, elucidating efficacious chemotherapeutic procedures are needed to diminish the likelihood of recurrence and metastasis. Erianin (Shihu, Traditional Chinese Medicine), a naturally occurring compound derived from Dendrobium chrysotoxum Lindl., has been documented to possess anticancer and antioxidative properties. This review presented an overview of Erianin's (ER) involvement in cancer and elucidated the molecular mechanisms underlying its anticancer effect via regulating signaling pathways, including PI3K/AKT, MEK, JNK, NRF2/PLOOH, JAK/STAT3, GSK3β, and NLRP3/ROS pathways. All these mechanisms ultimately induce apoptosis via targeting mainly invasion, migration, and angiogenesis. This review is thus intended to include all possible recent progress in the anticancer efficacy of erianin and to justify the necessity for further investigation into its anticancer properties in the future.

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最新综述：通过针对几种人类癌症中几种失调的癌基因来解读鸢尾素的抑制潜力。

许多可食用的蔬菜和水果都含有大量的抗癌成分，包括酚类、维生素和生物碱化合物。癌症治疗主要包括手术、化疗和放疗，有时伴随快速复发和显著的副作用。因此，需要阐明有效的化疗程序，以减少复发和转移的可能性。Erianin（石虎，中药），一种天然化合物，来源于石斛。已被证明具有抗癌和抗氧化的特性。本文综述了erin在癌症中的作用，并阐明了erin通过调节信号通路（包括PI3K/AKT、MEK、JNK、NRF2/PLOOH、JAK/STAT3、GSK3β和NLRP3/ROS通路）发挥抗癌作用的分子机制。所有这些机制最终诱导细胞凋亡主要通过靶向侵袭、迁移和血管生成。因此，本综述旨在包括所有可能的最新进展，在抗癌功效和证明有必要进一步研究其抗癌特性在未来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current pharmaceutical design 医学-药学

CiteScore

6.30

自引率

0.00%

发文量

302

审稿时长

2 months

期刊介绍： Current Pharmaceutical Design publishes timely in-depth reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field. Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.