Excision of organic macrocycles from covalent organic frameworks.

IF 44.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2025-06-19 DOI:10.1126/science.adw4126

Roberto Sánchez-Naya,Juan Pablo Cavalieri,Jorge Albalad,Alba Cortés-Martínez,Kaiyu Wang,Carles Fuertes-Espinosa,Teodor Parella,Sara Fiori,Esteve Ribas,Aitor Mugarza,Xavi Ribas,Jordi Faraudo,Omar M Yaghi,Inhar Imaz,Daniel Maspoch

引用次数: 0

Abstract

Molecules are typically synthesized through stepwise processes involving chemical reactions between simple molecular precursors. Here, we report an advance in the synthesis of new organic molecules based on the approach of clip-off chemistry, in which molecules are excised from ordered, extended organic structures. We synthesized macrocycles by selectively cleaving them out of covalent organic frameworks. The synthesized macrocycles include eight macrocyclic polyamides with 114-, 138-, and 162-atom rings, and one 114-atom ring macrocyclic polyimide. This excision approach expands the scope of chemical organic synthesis to previously inaccessible macromolecules.

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从共价有机框架中去除有机大环。

分子通常是通过简单分子前体之间的化学反应逐步合成的。在这里，我们报告了基于剪断化学方法合成新有机分子的进展，其中分子从有序的，扩展的有机结构中切除。我们通过选择性地将它们从共价有机框架中分离出来合成了大环。合成的大环包括8个114、138和162原子环的大环聚酰胺和1个114原子环的大环聚酰亚胺。这种切除方法将化学有机合成的范围扩展到以前无法进入的大分子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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