Juan P Zuniga-Hertz, Sierra Simpson, Ramamurthy Chitetti, Chang Francis Hsu, Han-Ping Huang, Alex Jinich-Diamant, Andrei V Chernov, Julie A Onton, Raphael Cuomo, Joe Dispenza, Dylan Davis, Leonardo Christov-Moore, Nicco Reggente, Wanjun Gu, Mitchell Kong, Jacqueline A Bonds, Jacqueline Maree, Tatum S Simonson, Andrew C Ahn, Michelle A Poirier, Tobias Moeller-Bertram, Hemal H Patel
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引用次数: 0
Abstract
Objectives: Meditation has long been known to promote health. We utilized a multidisciplinary approach to investigate the impact of mind-body interventions on the body in a twin cohort during a week-long meditation retreat.
Method: This study was designed to address individual changes controlling for intersubject trait variation and explore the role of genetic background on multi-omic factors during meditation. Transcriptomic analysis was carried out from whole blood samples, while metabolomic and biochemical studies were carried out in blood plasma. Quantitative electroencephalography studies, coupled with biometric analysis and molecular studies at multiple time points, were carried out in twins meditating together and in twins separated and simultaneously either meditating or listening to a documentary.
Results: Changes in gene expression, metabolites, and cytokines in blood plasma associated with specific meditative states showed patterns of change relative to the time point being assessed. Twin sets were similar in multiple domains before the start of the retreat, showed considerable divergence at the mid-point, and looked more similar by the end of the retreat. Twin pairs showed significant spectral power correlations in separate rooms and when only one twin meditated. These similarities were not observed in mismatched twin pairs. Heart rate dynamics assessments showed alignment among twin pairs, absent between unmatched pairs.
Conclusions: To our knowledge, this pilot study is novel within the twin research paradigm and is a first step toward exploring the effects of meditation in twins.
Preregistration: This study was not preregistered and was carried out under IRB protocol MED02#20211477.
Supplementary information: The online version contains supplementary material available at 10.1007/s12671-025-02584-x.
期刊介绍：
Mindfulness seeks to advance research, clinical practice, and theory on mindfulness. It is interested in manuscripts from diverse viewpoints, including psychology, psychiatry, medicine, neurobiology, psychoneuroendocrinology, cognitive, behavioral, cultural, philosophy, spirituality, and wisdom traditions. Mindfulness encourages research submissions on the reliability and validity of assessment of mindfulness; clinical uses of mindfulness in psychological distress, psychiatric disorders, and medical conditions; alleviation of personal and societal suffering; the nature and foundations of mindfulness; mechanisms of action; and the use of mindfulness across cultures. The Journal also seeks to promote the use of mindfulness by publishing scholarly papers on the training of clinicians, institutional staff, teachers, parents, and industry personnel in mindful provision of services. Examples of topics include: Mindfulness-based psycho-educational interventions for children with learning, emotional, and behavioral disorders Treating depression and clinical symptoms in patients with chronic heart failure Yoga and mindfulness Cognitive-behavioral mindfulness group therapy interventions Mindfulnessness and emotional regulation difficulties in children Loving-kindness meditation to increase social connectedness Training for parents and children with ADHD Recovery from substance abuse Changing parents’ mindfulness Child management skills Treating childhood anxiety and depression
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