Fucoidan-based delivery systems: From fabrication strategies to applications

IF 7 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Food Research International Pub Date : 2025-06-12 DOI:10.1016/j.foodres.2025.116752

Wenhao Liu , Xiaoye Xu , Lihui Duan , Xianyang Xie , Xinxin Zeng , Yan Huang , Yuanzhao Li , Zijian Zhi , Jie Pang , Chunhua Wu

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Abstract

Bioactive compounds such as curcumin, anthocyanidins, and quercetin demonstrate multifunctional therapeutic properties, including antioxidant, anticancer, and anti-inflammatory activities. However, their practical application is hindered by inherent physicochemical challenges, notably poor aqueous solubility and environmental sensitivity, which compromise bioavailability and efficacy. To overcome these limitations, advanced biopolymer-based delivery systems have gained prominence as innovative strategies. Among natural polymers, fucoidan—a sulfated marine polysaccharide with unique structural features and intrinsic bioactivity—has emerged as a versatile carrier for diverse delivery platforms. This review first outlines the structural and functional characteristics of fucoidan, followed by a critical analysis of its applications in nanoparticle, emulsion, hydrogel, and film-based delivery systems. Furthermore, novel engineering approaches, such as aerogel design and lipid complexation, are highlighted for their potential to expand fucoidan's utility in tailored delivery solutions. While previous reviews have addressed fucoidan-related research, this study presents the first three-dimensional integrated analysis encompassing structural characteristics, fabrication strategies, and functional applications of fucoidan-based systems. By synthesizing current advancements and identifying future directions, this review aims to advance the rational development of fucoidan-based technologies for enhanced functional food applications and related industrial innovations.

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岩藻胶基输送系统：从制造策略到应用

生物活性化合物如姜黄素、花青素和槲皮素显示出多功能治疗特性，包括抗氧化、抗癌和抗炎活性。然而，它们的实际应用受到固有的物理化学挑战的阻碍，特别是水溶性差和环境敏感性，从而影响了生物利用度和功效。为了克服这些限制，先进的基于生物聚合物的输送系统作为一种创新策略得到了重视。在天然聚合物中，岩藻糖烷是一种具有独特结构特征和内在生物活性的硫酸酸化海洋多糖，已成为多种给药平台的多功能载体。本文首先概述了岩藻糖聚糖的结构和功能特征，然后对其在纳米颗粒、乳液、水凝胶和基于膜的递送系统中的应用进行了批判性分析。此外，新的工程方法，如气凝胶设计和脂质络合，因其在量身定制的递送解决方案中扩大褐藻聚糖的效用的潜力而受到重视。虽然以前的综述已经讨论了岩藻胶相关的研究，但本研究首次提出了三维综合分析，包括岩藻胶基系统的结构特征、制造策略和功能应用。通过对目前研究进展的综合和对未来发展方向的展望，本文旨在促进岩藻胶基技术的合理发展，以增强功能性食品的应用和相关的产业创新。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food Research International 工程技术-食品科技

CiteScore

12.50

自引率

7.40%

发文量

1183

审稿时长

79 days

期刊介绍： Food Research International serves as a rapid dissemination platform for significant and impactful research in food science, technology, engineering, and nutrition. The journal focuses on publishing novel, high-quality, and high-impact review papers, original research papers, and letters to the editors across various disciplines in the science and technology of food. Additionally, it follows a policy of publishing special issues on topical and emergent subjects in food research or related areas. Selected, peer-reviewed papers from scientific meetings, workshops, and conferences on the science, technology, and engineering of foods are also featured in special issues.