The Effect of Green Tea Beverage on Blood Cardiometabolic Risk Biomarkers in Dyslipidemia Subjects

IF 3.8 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Food Science & Nutrition Pub Date : 2025-06-17 DOI:10.1002/fsn3.70415

Tikhamporn Pormlikul, Nattira On-Nom, Uthaiwan Suttisansanee, Piya Temviriyanukul, Dunyaporn Trachootham, Chanakan Khemthong, Niramol Muangpracha, Sirinapa Thangsiri, Khemika Praengam, Chaowanee Chupeerach

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Abstract

Green tea bioactive compounds show promise as a potential functional food to improve blood lipid profiles and ameliorate cardiovascular diseases. To determine the effect of 6 weeks of green tea compared to the placebo beverage consumption on blood cardiometabolic biomarkers. A randomized double-blinded placebo-controlled trial was conducted on dyslipidemia participants and randomly allocated in green tea beverage (n = 30) and placebo beverage (n = 30) groups. Sixty dyslipidemia adults with age 30–60 years old participated. Change in blood parameters, including lipid profiles, liver and kidney functions, oxidative stress and antioxidant markers, gene expressions, and anthropometric parameters, was measured. After 6 weeks of green tea intervention, blood total cholesterol and low-density lipoprotein cholesterol (LDL) decreased in the green tea group by 4.96% and 7.98%, respectively. Plasma malondialdehyde (MDA), a lipid peroxidation marker, decreased, whereas antioxidant capacities measured by the ferric ion reducing antioxidant power (FRAP) and oxygen radical absorbance capacity (ORAC) assays were maintained in the green tea beverage group. The lipid-related gene expression of peripheral blood mononuclear cells (PBMC) was observed by real-time polymerase chain reaction. The LDL receptor gene was upregulated in the green tea beverage group. The liver and kidney function tests showed no alterations among the subjects in the green tea beverage and placebo groups. Six weeks of green tea beverage intervention showed potential as a treatment to reduce cardiometabolic risk in dyslipidemia subjects.

Trial Registration: Thai Clinical Trial Registry: TCTR20250104003

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绿茶饮料对血脂异常受试者血液心血管代谢风险生物标志物的影响

绿茶生物活性化合物有望成为改善血脂和改善心血管疾病的潜在功能性食品。为了确定6周饮用绿茶与安慰剂饮料对血液心脏代谢生物标志物的影响。对血脂异常患者进行随机双盲安慰剂对照试验，随机分为绿茶饮料组（n = 30）和安慰剂饮料组（n = 30）。60名30-60岁的血脂异常成年人参与了研究。测量血脂、肝肾功能、氧化应激和抗氧化标志物、基因表达和人体测量参数等血液参数的变化。经过6周的绿茶干预，绿茶组的血液总胆固醇和低密度脂蛋白胆固醇（LDL）分别下降了4.96%和7.98%。血浆丙二醛（MDA）（脂质过氧化标志物）下降，而铁离子还原抗氧化能力（FRAP）和氧自由基吸收能力（ORAC）测定的抗氧化能力在绿茶饮料组保持不变。采用实时聚合酶链反应法观察外周血单核细胞（PBMC）脂质相关基因表达。低密度脂蛋白受体基因在绿茶饮料组上调。肝脏和肾脏功能测试显示绿茶饮料组和安慰剂组的受试者没有变化。六周的绿茶饮料干预显示出降低血脂异常受试者心脏代谢风险的潜力。试验注册：泰国临床试验注册：TCTR20250104003

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来源期刊

Food Science & Nutrition Agricultural and Biological Sciences-Food Science

CiteScore

7.40

自引率

5.10%

发文量

434

审稿时长

24 weeks

期刊介绍： Food Science & Nutrition is the peer-reviewed journal for rapid dissemination of research in all areas of food science and nutrition. The Journal will consider submissions of quality papers describing the results of fundamental and applied research related to all aspects of human food and nutrition, as well as interdisciplinary research that spans these two fields.