Molecular hydrogen therapy: A “democratic” emerging strategy against aging and age-related diseases

IF 12.4 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2025-06-13 DOI:10.1016/j.arr.2025.102802

Giovanni Brandi , Chiara Delbaldo , Marzia Deserti , Valeria Relli , Simone Rimedio , Andrea Palloni , Chiara Deiana , Gioconda Saccoccio , Raffaele Ingenito , Simona Tavolari

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引用次数: 0

Abstract

Aging represents the main risk factor for the development of several diseases, including cardiovascular and metabolic conditions, neurodegenerative disorders and cancer. As the number of elderly people is increasing worldwide, different strategies to counteract age-related diseases have been investigated. Recently, the use of molecular hydrogen (H₂) as a preventive and therapeutic approach has been proposed due to its antioxidant and anti-inflammatory properties, its ability to regulate cell senescence and death, and to restore intestinal eubiosis. Although the studies investigating the role of H₂ in slowing-down aging and age-related diseases are still limited, current findings support the idea that its administration may be able to affect different hallmarks of these processes. The “democratic” characteristics of H₂ rely on its potential widespread use due to its pleiotropic activity, the lack of toxicities and low costs. In this review we provide a comprehensive state of the art on current knowledge on the molecular and clinical features of aging and age-related diseases. Current therapeutic approaches to slow down these processes will be also discussed, with a main focus on the potential use of H₂ as an innovative preventive and therapeutic strategy.

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分子氢疗法：一种对抗衰老和与年龄相关疾病的“民主”新兴策略。

衰老是几种疾病发展的主要风险因素，包括心血管和代谢疾病、神经退行性疾病和癌症。随着世界范围内老年人数量的增加，人们研究了不同的战略来对抗与年龄有关的疾病。近年来，由于其抗氧化和抗炎特性、调节细胞衰老和死亡以及恢复肠道益生的能力，分子氢（H2）被提出作为一种预防和治疗方法。尽管研究H2在延缓衰老和年龄相关疾病中的作用仍然有限，但目前的研究结果支持这样的观点，即H2的施用可能能够影响这些过程的不同标志。H2的“民主”特性取决于其多效性、低毒性和低成本的潜在广泛应用。在这篇综述中，我们提供了一个全面的状态，目前的知识在分子和临床特征的老化和年龄相关疾病。还将讨论当前减缓这些过程的治疗方法，主要关注氢气作为一种创新的预防和治疗策略的潜在用途。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.