{"title":"Traditional Chinese herbal medicines for the treatment of ischemic stroke in China","authors":"Xiaomeng Dong , Tianya Zhang , Cong Zhang , Wenyan Shang , Yuqing Zhang , Xiangjian Zhang","doi":"10.1016/j.arr.2025.102803","DOIUrl":null,"url":null,"abstract":"<div><div>Ischemic stroke (IS) is a devastating disease with high disability and mortality rates worldwide. Despite advances in medical treatment, managing IS remains a significant challenge. In China, traditional Chinese herbal medicines (TCHMs) are often sought as alternative pharmacotherapies for both prevention and rehabilitation because of their proven efficacy and relatively low incidence of adverse reactions. While TCHMs do have certain limitations, their value cannot be overlooked. Centuries of clinical experience in China have established TCHMs as promising approaches for improving clinical outcomes and accelerating drug discovery in the treatment of IS. In this review, we summarize the potential mechanisms and clinical evidence of TCHMs in the treatment of IS in China. These findings suggest that TCHMs can treat IS through various pharmacological mechanisms, mainly anti-inflammatory, antiapoptotic, antioxidative stress, and mitochondrial regulatory mechanisms. Additionally, TCHMs provide protection to the blood-brain barrier, inhibit excitotoxicity, promote angiogenesis, reduce ferroptosis, modulate the gut-brain axis, prevent thrombosis, improve blood rheology, and regulate neural stem cells. These effects contribute to improved therapeutic outcomes at various stages of IS and poststroke complications, especially when combined with Western medicine, while also offering a favorable safety profile. In conclusion, TCHMs represent a promising strategy for managing IS and advancing related drug development. We hope that this review will inspire further exploration into the mechanisms underlying the anti-IS effects of TCHMs, thereby enhancing the scientific understanding of traditional Chinese medicine.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"110 ","pages":"Article 102803"},"PeriodicalIF":12.4000,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ageing Research Reviews","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1568163725001497","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Ischemic stroke (IS) is a devastating disease with high disability and mortality rates worldwide. Despite advances in medical treatment, managing IS remains a significant challenge. In China, traditional Chinese herbal medicines (TCHMs) are often sought as alternative pharmacotherapies for both prevention and rehabilitation because of their proven efficacy and relatively low incidence of adverse reactions. While TCHMs do have certain limitations, their value cannot be overlooked. Centuries of clinical experience in China have established TCHMs as promising approaches for improving clinical outcomes and accelerating drug discovery in the treatment of IS. In this review, we summarize the potential mechanisms and clinical evidence of TCHMs in the treatment of IS in China. These findings suggest that TCHMs can treat IS through various pharmacological mechanisms, mainly anti-inflammatory, antiapoptotic, antioxidative stress, and mitochondrial regulatory mechanisms. Additionally, TCHMs provide protection to the blood-brain barrier, inhibit excitotoxicity, promote angiogenesis, reduce ferroptosis, modulate the gut-brain axis, prevent thrombosis, improve blood rheology, and regulate neural stem cells. These effects contribute to improved therapeutic outcomes at various stages of IS and poststroke complications, especially when combined with Western medicine, while also offering a favorable safety profile. In conclusion, TCHMs represent a promising strategy for managing IS and advancing related drug development. We hope that this review will inspire further exploration into the mechanisms underlying the anti-IS effects of TCHMs, thereby enhancing the scientific understanding of traditional Chinese medicine.
期刊介绍:
With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends.
ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research.
The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.