Traditional Chinese herbal medicines for the treatment of ischemic stroke in China

IF 12.4 1区 医学 Q1 CELL BIOLOGY
Xiaomeng Dong , Tianya Zhang , Cong Zhang , Wenyan Shang , Yuqing Zhang , Xiangjian Zhang
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Abstract

Ischemic stroke (IS) is a devastating disease with high disability and mortality rates worldwide. Despite advances in medical treatment, managing IS remains a significant challenge. In China, traditional Chinese herbal medicines (TCHMs) are often sought as alternative pharmacotherapies for both prevention and rehabilitation because of their proven efficacy and relatively low incidence of adverse reactions. While TCHMs do have certain limitations, their value cannot be overlooked. Centuries of clinical experience in China have established TCHMs as promising approaches for improving clinical outcomes and accelerating drug discovery in the treatment of IS. In this review, we summarize the potential mechanisms and clinical evidence of TCHMs in the treatment of IS in China. These findings suggest that TCHMs can treat IS through various pharmacological mechanisms, mainly anti-inflammatory, antiapoptotic, antioxidative stress, and mitochondrial regulatory mechanisms. Additionally, TCHMs provide protection to the blood-brain barrier, inhibit excitotoxicity, promote angiogenesis, reduce ferroptosis, modulate the gut-brain axis, prevent thrombosis, improve blood rheology, and regulate neural stem cells. These effects contribute to improved therapeutic outcomes at various stages of IS and poststroke complications, especially when combined with Western medicine, while also offering a favorable safety profile. In conclusion, TCHMs represent a promising strategy for managing IS and advancing related drug development. We hope that this review will inspire further exploration into the mechanisms underlying the anti-IS effects of TCHMs, thereby enhancing the scientific understanding of traditional Chinese medicine.
中国治疗缺血性中风的中草药。
缺血性中风(IS)是世界范围内致残率和死亡率高的一种毁灭性疾病。尽管医学治疗取得了进步,但管理IS仍然是一项重大挑战。在中国,传统中草药(TCHMs)由于其被证实的疗效和相对较低的不良反应发生率,经常被寻求作为预防和康复的替代药物治疗。虽然tchm确实有一定的局限性,但它们的价值不容忽视。几个世纪以来,中国的临床经验已经证明中药是改善临床结果和加速IS治疗药物发现的有希望的方法。在这篇综述中,我们总结了中药治疗IS的潜在机制和临床证据。这些发现表明中药可以通过多种药理机制治疗IS,主要是抗炎、抗凋亡、抗氧化应激和线粒体调节机制。此外,中药还具有保护血脑屏障、抑制兴奋毒性、促进血管生成、减少铁质凋亡、调节肠脑轴、预防血栓形成、改善血液流变学和调节神经干细胞的作用。这些作用有助于改善不同阶段IS和卒中后并发症的治疗结果,特别是与西药联合使用时,同时也提供了良好的安全性。总之,中药代表了一种很有前途的策略来管理IS和推进相关药物的开发。我们希望这一综述能够启发我们进一步探索中药抗is作用的机制,从而增强对中药的科学认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Ageing Research Reviews
Ageing Research Reviews 医学-老年医学
CiteScore
19.80
自引率
2.30%
发文量
216
审稿时长
55 days
期刊介绍: With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.
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