Effect of curcumin on cardiometabolic diseases in the elderly: A systematic review of randomized controlled trials

IF 12.4 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2025-06-12 DOI:10.1016/j.arr.2025.102801

Fatemeh Rajabinasab , Faeze Sadat Ahmadi Tabatabaei , Ali Kheirandish , Pooya Hajimirzaei , Sajad Abolfazli , Ademuyiwa S. Aromolaran , Tannaz Jamialahmadi , Amirhossein Sahebkar

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引用次数: 0

Abstract

Introduction

As people age, the incidence of cardiometabolic diseases rises, negatively impacting their quality of life; therefore, it is important to supplement the diet with compounds that can manage these conditions. Curcumin (Cur), a common dietary spice, may benefit the health of the elderly. This systematic review evaluates Cur’s effectiveness in improving cardiometabolic disease symptoms.

Methods

Relevant studies were identified from searches conducted in Scopus, Embase, and PubMed. The risk of bias was assessed using the Cochrane Risk of Bias 2 (RoB 2) tool.

Results and Discussion

Seven randomized controlled trials (RCTs) were included. Cur supplementation (CurS) in elderly individuals resulted in significant improvements in several metabolic and inflammatory markers, including reductions in C-reactive protein (CRP) (p = 0.03), systolic blood pressure (p = 0.04), fasting blood sugar (p = 0.02), and HOMA-IR (p = 0.01) compared with controls. Additionally, a significant decrease in triglyceride levels (p = 0.04) and an increase in HDL (p = 0.03) were observed. However, effects on other cardiovascular indices were inconsistent across the studies.

Conclusions

These findings suggest that Cur may serve as an adjunctive therapy for age-related cardiometabolic diseases; however, variability in outcomes and protocols limits the ability to make broad recommendations. Future research should focus on large, well-powered RCTs with standardized dosing, formulations, and treatment durations, including long-term follow-up to assess sustained efficacy and delayed adverse effects. Comprehensive safety monitoring and detailed documentation of supplement composition and patient characteristics are also needed to clarify heterogeneity and identify those at higher risk for complications.

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姜黄素对老年人心脏代谢疾病的影响：随机对照试验的系统综述。

随着人们年龄的增长，心脏代谢疾病的发病率上升，对他们的生活质量产生负面影响；因此，在饮食中补充能够控制这些疾病的化合物是很重要的。姜黄素（Cur）是一种常见的膳食香料，可能有益于老年人的健康。本系统综述评价了Cur在改善心脏代谢疾病症状方面的有效性。方法：从Scopus、Embase和PubMed中检索相关研究。使用Cochrane risk of bias 2 （RoB 2）工具评估偏倚风险。结果与讨论：纳入7项随机对照试验（RCTs）。与对照组相比，老年人补充Cur （CurS）可显著改善几种代谢和炎症标志物，包括降低c反应蛋白（CRP）（p=0.03）、收缩压（p=0.04）、空腹血糖（p=0.02）和HOMA-IR （p=0.01）。此外，观察到甘油三酯水平显著降低（p=0.04），高密度脂蛋白水平显著升高（p=0.03）。然而，对其他心血管指标的影响在研究中并不一致。结论：这些发现表明，Cur可能作为一种辅助治疗与年龄相关的心脏代谢疾病；然而，结果和方案的可变性限制了提出广泛建议的能力。未来的研究应侧重于采用标准化剂量、配方和治疗持续时间的大型、有效的随机对照试验，包括长期随访，以评估持续疗效和延迟不良反应。还需要对补充剂成分和患者特征进行全面的安全性监测和详细的文件记录，以澄清异质性并确定并发症风险较高的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.