Dietary total antioxidant capacity and polyphenol intake benefit the inflammatory profile and HDL-C concentrations in individuals with metabolic syndrome

IF 3.1 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research Pub Date : 2025-05-18 DOI:10.1016/j.nutres.2025.05.002

Talita do Nascimento Peixoto , Layne Christina Benedito de Assis Lima , Josivan Gomes Lima , Karine Cavalcanti Maurício Sena-Evangelista , Renata Alves Carnauba , Franco Maria Lajolo , Lucia Fátima Campos Pedrosa

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引用次数: 0

Abstract

The total dietary antioxidant capacity (DTAC) and dietary polyphenol intake (DPI) have been studied for their potential to improve metabolic profiles. However, their relationship with all the components of metabolic syndrome (MetS) and inflammatory parameters in individuals diagnosed with MetS remains underexplored, particularly in Brazil. We hypothesized that higher DTAC and DPI concentrations would be associated with better metabolic profiles in individuals with MetS. This study aimed to evaluate the simultaneous effects of DTAC and DPI on MetS components and high-sensitivity C-reactive protein (hs-CRP) concentrations. This cross-sectional study included 224 individuals with MetS recruited from an endocrinology outpatient clinic at a university hospital in Brazil. Sociodemographic and clinical data were collected along with two 24-hour dietary recalls. DTAC was estimated from food consumption data measured using the ferric-reducing antioxidant potential method. The DPI was obtained from the databases of Phenol Explorer and the United States Department of Agriculture. Binary logistic regression models were used to assess the association of DTAC and DPI with triglyceride, fasting glucose, HDL-C, waist circumference, blood pressure, and hs-CRP concentrations. The results indicated that higher intakes of DTAC, total polyphenols, and phenolic acids were associated with reduced hs-CRP concentrations, suggesting anti-inflammatory benefits in individuals with MetS. Furthermore, increased flavonoid intake was linked to higher HDL-C concentration, suggesting a favorable effect on lipid metabolism. In conclusion, these findings suggest the incorporation of antioxidant- and polyphenol-rich foods into dietary recommendations for managing inflammation and preventing dyslipidemia in individuals with MetS. These findings should be interpreted with caution because cross-sectional studies cannot determine causality.

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饮食中的总抗氧化能力和多酚摄入有利于代谢综合征患者的炎症特征和HDL-C浓度

研究了日粮总抗氧化能力（DTAC）和日粮多酚摄入量（DPI）改善代谢谱的潜力。然而，它们与代谢综合征（MetS）的所有组成部分和诊断为MetS的个体的炎症参数的关系仍未得到充分研究，特别是在巴西。我们假设较高的DTAC和DPI浓度与met患者更好的代谢谱有关。本研究旨在评估DTAC和DPI对MetS成分和高敏c反应蛋白（hs-CRP）浓度的同时影响。这项横断面研究包括从巴西一所大学医院的内分泌门诊部招募的224名met患者。社会人口学和临床数据与两次24小时饮食回顾一起收集。DTAC是通过使用铁还原抗氧化电位法测量的食品消费数据来估计的。DPI从苯酚探索者和美国农业部的数据库中获得。采用二元logistic回归模型评估DTAC和DPI与甘油三酯、空腹血糖、HDL-C、腰围、血压和hs-CRP浓度的关系。结果表明，较高的DTAC、总多酚和酚酸摄入量与hs-CRP浓度降低有关，表明MetS患者具有抗炎作用。此外，增加的类黄酮摄入量与较高的HDL-C浓度有关，表明对脂质代谢有有利影响。总之，这些研究结果表明，将富含抗氧化剂和多酚的食物纳入MetS患者的饮食建议中，以控制炎症和预防血脂异常。这些发现应谨慎解释，因为横断面研究不能确定因果关系。

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来源期刊

Nutrition Research 医学-营养学

CiteScore

7.60

自引率

2.20%

发文量

107

审稿时长

58 days

期刊介绍： Nutrition Research publishes original research articles, communications, and reviews on basic and applied nutrition. The mission of Nutrition Research is to serve as the journal for global communication of nutrition and life sciences research on diet and health. The field of nutrition sciences includes, but is not limited to, the study of nutrients during growth, reproduction, aging, health, and disease. Articles covering basic and applied research on all aspects of nutrition sciences are encouraged, including: nutritional biochemistry and metabolism; metabolomics, nutrient gene interactions; nutrient requirements for health; nutrition and disease; digestion and absorption; nutritional anthropology; epidemiology; the influence of socioeconomic and cultural factors on nutrition of the individual and the community; the impact of nutrient intake on disease response and behavior; the consequences of nutritional deficiency on growth and development, endocrine and nervous systems, and immunity; nutrition and gut microbiota; food intolerance and allergy; nutrient drug interactions; nutrition and aging; nutrition and cancer; obesity; diabetes; and intervention programs.