The relationship between dietary index for gut microbiota and hyperuricemia: a cross-sectional study using NHANES data.

IF 4 2区农林科学 Q2 NUTRITION & DIETETICS

Frontiers in Nutrition Pub Date : 2025-05-26 eCollection Date: 2025-01-01 DOI:10.3389/fnut.2025.1580122

Xin Cai, Shaoqin Zhang, Tianzuo Lan, Zexu Jin, Jiajun Liu, Zong Jiang, Qingwan Yang

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引用次数: 0

Abstract

Background: Hyperuricemia (HUA) is a common metabolic disorder, yet the impact of diet and gut microbiota on uric acid metabolism remains insufficiently understood. This study aims to investigate the relationship between the dietary index for gut microbiota (DI-GM) and HUA using data from the National Health and Nutrition Examination Survey (NHANES).

Methods: This study employed NHANES data gathered from 2007 to 2020, encompassing 25,899 adults aged 18 years and older. The DI-GM, which spans from 0 to 14, was calculated based on dietary recall information. The diagnosis of HUA was established through laboratory findings. To examine the relationship between DI-GM and HUA, multivariable logistic regression was utilized, accounting for pertinent confounding variables.

Results: Upon adjusting for possible confounding variables, an elevated DI-GM score demonstrated a notable correlation with a reduced likelihood of HUA [odds ratio (OR) = 0.968, 95% confidence interval (CI) = 0.949-0.987, p = 0.005]. Subjects exhibiting a DI-GM score of ≥6 demonstrated a markedly reduced risk of HUA in contrast to those scoring between 0 and 3 (OR = 0.897, 95% CI = 0.821-0.980, p = 0.016).

Conclusion: A higher DI-GM score is inversely related to the risk of HUA.

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肠道微生物群膳食指数与高尿酸血症之间的关系：一项使用NHANES数据的横断面研究。

背景：高尿酸血症（HUA）是一种常见的代谢性疾病，但饮食和肠道菌群对尿酸代谢的影响尚不清楚。本研究旨在利用美国国家健康与营养调查（NHANES）的数据，探讨肠道微生物群膳食指数（DI-GM）与HUA之间的关系。方法：本研究采用2007年至2020年收集的NHANES数据，包括25,899名18岁及以上的成年人。DI-GM的取值范围为0 ~ 14，是根据膳食召回信息计算的。HUA的诊断是通过实验室检查确定的。为了检验DI-GM和HUA之间的关系，我们使用了多变量逻辑回归，考虑了相关的混杂变量。结果：在对可能的混杂变量进行调整后，DI-GM评分升高与HUA可能性降低有显著相关性[比值比(OR) = 0.968, 95%可信区间(CI) = 0.949-0.987, p = 0.005]。DI-GM评分≥6的受试者与评分在0 - 3之间的受试者相比，HUA的风险显著降低（OR = 0.897, 95% CI = 0.821-0.980, p = 0.016）。结论：较高的DI-GM评分与HUA风险呈负相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Nutrition Agricultural and Biological Sciences-Food Science

CiteScore

5.20

自引率

8.00%

发文量

2891

审稿时长

12 weeks

期刊介绍： No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health. Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.