SUPRAS-based generic sample treatment for determination of twelve regulated mycotoxins in five food commodity groups

IF 9.8 1区农林科学 Q1 CHEMISTRY, APPLIED

Food Chemistry Pub Date : 2025-06-10 DOI:10.1016/j.foodchem.2025.145092

Luis Muñiz-Bustamante, Noelia Caballero-Casero, Soledad Rubio

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Abstract

A generic sample preparation method based on supramolecular solvents (SUPRAS) was developed and combined with liquid chromatography–tandem mass spectrometry (LC-MS/MS) to determine twelve regulated mycotoxins in five food commodity groups. The SUPRAS was produced by coacervation of 1-hexanol in a water-tetrahydrofuran (THF) mixture. The extraction and clean-up were combined into a single step, thanks to the restricted access properties of the SUPRAS. The procedure was simple (only required sample stirring and centrifugation) and significantly reduced solvent consumption (0.8 mL of THF per sample). Method quantification limits ranged 0.03–23.95 ng/mL for each of the mycotoxins/food sample combinations. Repeatability, within-laboratory reproducibility, and trueness values ranged 3–20 %, 3–18 %, and 69–115 %, respectively. The SUPRAS-LC-MS/MS method was fully compliant with EC regulations for all the food categories, regulated mycotoxins, and investigated concentration levels. Thus, it offers a quick, sustainable and cost-effective approach to the routine control of mycotoxins in food.

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基于supra的通用样品处理方法测定5类食品商品中12种受管制真菌毒素

建立了一种基于超分子溶剂的通用样品制备方法（SUPRAS），并将其与液相色谱-串联质谱（LC-MS/MS）相结合，用于测定5类食品中12种受管制真菌毒素。SUPRAS是由1-己醇在水-四氢呋喃（THF）混合物中凝聚而成。由于SUPRAS的限制进入特性，提取和清理被合并为一个步骤。程序简单（只需要样品搅拌和离心），并显著减少溶剂消耗（每个样品0.8 mL THF）。方法每种真菌毒素/食品样品组合的定量限为0.03 ~ 23.95 ng/mL。重复性、实验室内重现性和真实度分别为3-20 %、3-18 %和69-115 %。SUPRAS-LC-MS/MS方法完全符合欧盟法规，适用于所有食品类别、受管制的真菌毒素和所调查的浓度水平。因此，它为食品中真菌毒素的常规控制提供了一种快速、可持续和具有成本效益的方法。

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来源期刊

Food Chemistry 工程技术-食品科技

CiteScore

16.30

自引率

10.20%

发文量

3130

审稿时长

122 days

期刊介绍： Food Chemistry publishes original research papers dealing with the advancement of the chemistry and biochemistry of foods or the analytical methods/ approach used. All papers should focus on the novelty of the research carried out.