Implications of sociodemographic and clinical factors on symptom burden: Age-specific survivorship care in the primary central nervous system tumor population.

IF 2.5 Q2 CLINICAL NEUROLOGY

Neuro-oncology practice Pub Date : 2024-11-26 eCollection Date: 2025-06-01 DOI:10.1093/nop/npae116

Kimberly R Robins, Tricia Kunst, Jennifer Reyes, Alvina Acquaye-Mallory, Ewa Grajkowska, Byram H Ozer, Marta Penas-Prado, Jing Wu, Eric Burton, Lisa Boris, Marissa Panzer, Tina Pillai, Lily Polskin, Mark R Gilbert, Elizabeth Vera, Terri S Armstrong

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引用次数: 0

Abstract

Background: This analysis aims to provide insight into differences in symptom burden and general health status between young adults (YA; 18-39 years old) and older adults (OA; ≥40 years old) with primary central nervous system tumors.

Methods: Data were retrospectively analyzed from the National Cancer Institute Neuro-Oncology Branch's Natural History Study (NCT02851706 PI: T.S. Armstrong) to determine differences in patient-reported outcomes (general health status [EQ-5D-3L], symptom burden [MDASI-BT and MDASI-SP], anxiety/depression [Patient-Reported Outcomes Measurement Information System], and perceived cognition [Neuro-QOL]) and demographic and clinical data using chi-square, one-way ANOVA, and Student's t-tests. Linear regression with backward elimination determined which characteristics impacted perceived symptom burden and general health status.

Results: The sample included 271 YA (82% with a primary brain tumor (PBT); median age 31 [range, 18-39]) and 516 OA (88% with a PBT; median age 54 [range, 40-85]). YA were more likely to be single (P < .001), employed (P < .001), and make < $50 000 per year (P = .014). More YA reported pain (P = .008), nausea (P < .001), drowsiness (P = .043), and vomiting (P = .001) than OA. Among demographic and clinical characteristics, when controlling for age, Karnofsky Performance Scale score (P < .001) and employment status (P < .001) were predictors of symptom interference, activity- and mood-related interference in patients with PBTs. Compared to OA with spinal tumors, YA reported more moderate-severe anxiety (P = .050) and moderate-severe perceived cognitive deficits (P = .023).

Conclusions: Significant differences in characteristics and symptom burden exist between YA and OA. Developmentally tailored survivorship programs providing additional psychosocial support and resources to address symptom presentation in YA are needed.

查看原文本刊更多论文

社会人口学和临床因素对症状负担的影响：原发性中枢神经系统肿瘤人群的年龄特异性生存护理。

背景：本分析旨在了解青壮年(YA；18-39岁)和老年人(OA；≥40岁)伴有原发性中枢神经系统肿瘤。方法：回顾性分析来自美国国家癌症研究所神经肿瘤学分支自然史研究（NCT02851706 PI: T.S. Armstrong）的数据，以确定患者报告的结局（一般健康状况[iq - 5d - 3l]、症状负担[MDASI-BT和MDASI-SP]、焦虑/抑郁[患者报告的结局测量信息系统]和感知认知[neuroqol]）以及人口统计学和临床数据的差异，采用卡方、单因素方差分析和学生t检验。线性回归与反向消除确定哪些特征影响感知症状负担和一般健康状况。结果：样本包括271例YA（82%伴有原发性脑肿瘤）；中位年龄31岁[范围，18-39岁])和516 OA(88%伴PBT；中位年龄54岁[范围40-85岁])。男性更可能是单身（P P P = .014）。YA报告的疼痛（P = 0.008）、恶心（P = 0.043）和呕吐（P = 0.001）多于OA。在人口学和临床特征中，在控制年龄、Karnofsky绩效量表评分（P P = 0.050）和中重度感知认知缺陷（P = 0.023）的情况下。结论：骨性关节炎与骨性关节炎的特征及症状负担存在显著差异。需要发展量身定制的生存计划，提供额外的社会心理支持和资源，以解决YA的症状表现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuro-oncology practice CLINICAL NEUROLOGY-

CiteScore

5.30

自引率

11.10%

发文量

期刊介绍： Neuro-Oncology Practice focuses on the clinical aspects of the subspecialty for practicing clinicians and healthcare specialists from a variety of disciplines including physicians, nurses, physical/occupational therapists, neuropsychologists, and palliative care specialists, who have focused their careers on clinical patient care and who want to apply the latest treatment advances to their practice. These include: Applying new trial results to improve standards of patient care Translating scientific advances such as tumor molecular profiling and advanced imaging into clinical treatment decision making and personalized brain tumor therapies Raising awareness of basic, translational and clinical research in areas of symptom management, survivorship, neurocognitive function, end of life issues and caregiving