Effects of Early Weight Trends on Residential Treatment Outcomes Among Adolescents With Anorexia Nervosa

IF 4.3 2区医学 Q1 NUTRITION & DIETETICS

International Journal of Eating Disorders Pub Date : 2025-06-05 DOI:10.1002/eat.24480

Simar Singh, Sasha Gorrell, Catherine R. Drury, Alan Duffy, Philip S. Mehler, Kianna Zucker, Daniel Le Grange, Erin E. Reilly, Renee D. Rienecke

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Abstract

Background

Weight variability (WV), or daily-to-weekly fluctuations in weight, associates with increased eating pathology in adults with bulimia nervosa and greater weight gain across the developmental span in healthy controls, but few studies have explored these relations in adolescents with anorexia nervosa (AN). Given the importance of early weight gain during treatment for AN prognosis, WV could impact outcomes via effects on weight trends and related psychopathology. The current study examined whether WV and the slope of weight change predict eating disorder symptoms at the end of treatment (EOT) among adolescents with AN.

Method

Adolescents with AN (N = 284) receiving residential treatment completed the Eating Disorder Examination Questionnaire (EDE-Q) at admission and EOT. WV was calculated using the root-mean-squared-error of daily weights over the first 14 days of treatment. Linear regressions examined the effect of WV, slope of weight change over 14 days, and their interaction on percent expected body weight (%EBW) and EDE-Q scores at EOT.

Results

WV positively predicted EDE-Q Global Score (p = 0.033, sr ² = 0.01), Shape Concern (p = 0.026, sr ² = 0.01), and Weight Concern (p = 0.008, sr ² = 0.02) at EOT. Neither WV nor the slope of weight change predicted %EBW at EOT (ps > 0.05). The slope of weight change did not predict EDE-Q, nor did it moderate the relation between WV and any outcomes (ps > 0.05).

Conclusions

Patients who experience greater weight fluctuations early in treatment may be more susceptible to elevated psychopathology at discharge. In light of few significant effects and small effect sizes, more research is needed to determine the putative role of early weight trends in adolescent AN outcomes.

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青少年神经性厌食症患者早期体重趋势对住院治疗结果的影响。

背景：体重变异性（WV），或每日至每周的体重波动，与神经性贪食症成人的饮食病理增加和健康对照组在整个发育期间的体重增加有关，但很少有研究探讨青少年神经性厌食症（AN）的这些关系。考虑到早期体重增加对AN治疗预后的重要性，WV可能通过影响体重趋势和相关精神病理来影响结果。目前的研究考察了WV和体重变化斜率是否能预测AN青少年治疗结束时的饮食失调症状。方法：接受住院治疗的青少年AN （N = 284）在入院和治疗前填写进食障碍检查问卷（ed - q）。WV采用治疗前14天每日体重的均方根误差计算。线性回归检验了WV、14天内体重变化斜率的影响，以及它们对EOT时预期体重百分比（%EBW）和ed - q评分的相互作用。结果：WV正预测eet - q Global Score （p = 0.033, sr2 = 0.01）、Shape Concern （p = 0.026, sr2 = 0.01）和Weight Concern （p = 0.008, sr2 = 0.02）。WV和体重变化斜率都不能预测EOT时的%EBW （ps > 0.05）。体重变化的斜率不能预测ed - q，也不能调节WV与任何结局之间的关系（p < 0.05）。结论：在治疗早期经历较大体重波动的患者可能更容易在出院时出现精神病理升高。鉴于很少有显著的影响和较小的效应量，需要更多的研究来确定早期体重趋势在青少年AN结果中的假定作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Eating Disorders 医学-精神病学

CiteScore

10.00

自引率

12.70%

发文量

204

审稿时长

4-8 weeks

期刊介绍： Articles featured in the journal describe state-of-the-art scientific research on theory, methodology, etiology, clinical practice, and policy related to eating disorders, as well as contributions that facilitate scholarly critique and discussion of science and practice in the field. Theoretical and empirical work on obesity or healthy eating falls within the journal’s scope inasmuch as it facilitates the advancement of efforts to describe and understand, prevent, or treat eating disorders. IJED welcomes submissions from all regions of the world and representing all levels of inquiry (including basic science, clinical trials, implementation research, and dissemination studies), and across a full range of scientific methods, disciplines, and approaches.