Perspectives on Genetic and Environmental Factors in Myopia, Its Prediction, and the Future Direction of Research.

Abstract

The dramatic rise in myopia prevalence over the last century is most likely a function of modern-day childhood - a reduction in time spent outdoors and increasing time on near tasks. The widespread use of handheld digital devices, especially in young children, is of concern - both in terms of myopia risk but additionally that excessive use may be linked to sociodemographic factors and could more widely negatively affect health outcomes. Refractive error is a highly heritable trait, and genetic factors are the leading determinant of refractive status variation within a particular environment. Better understanding of these genetic factors could enable prediction of future myopia status, provide novel therapeutic avenues, and personalised treatment. Monitoring axial length growth of increasing interest, likely offering better identification of pre-myopia status and a more accurate correlate of risk of future visual complications. Prediction models are increasing in utility - comprising the aforementioned factors and artificial intelligence within this area is likely to increase. Population-based interventions, such as increased time outdoors, to reduce the incidence and/or slow myopia progression have shown some success, and combined approaches hold future promise. Children developing high myopia at a young age are most at risk of future complications, yet to date are a under researched cohort. Likewise, progression and potential modification of risk in young adults requires more research. The adoption of improved technology into this field to better quantify outdoor exposure and near activities alongside ocular growth, choroidal thickness and peripheral refractive changes in all mentioned cohorts is needed.