Retrospective Analysis of Liver Function Post Intravenous Ketamine for Treating Complex Regional Pain Syndrome.

IF 2.5 2区医学 Q2 ANESTHESIOLOGY

Pain physician Pub Date : 2025-05-01

Chanbin Lee, Philip Getson, Neel Mehta, Jay Joshi, Pradeep Chopra

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引用次数: 0

Abstract

Background: Complex Regional Pain Syndrome (CRPS) is a severely painful condition with very few effective treatments. One of the treatments used to treat CRPS is intravenous ketamine infusions. There has been one controversial anecdotal report on the effect of ketamine on liver dysfunction.

Objectives: This study aimed to determine the effect of ketamine on liver enzymes.

Study design: A retrospective study.

Setting: Multilocation Pain Management Centers.

Methods: During the treatment period from January 2010 through December 2018, the medical records of 52 patients were reviewed and analyzed. All of them had undergone an intravenous ketamine infusion for managing CRPS. As per protocol, a liver function test was performed within 24 hours postinfusion. The Brown University Human Research Protection Program determined that the proposed research did not involve human subjects as defined by 45 CFR Part 46.102.

Results: A retrospective chart review was performed as part of ongoing quality assessment. All of the patients had received multiple days of a loading dose of ketamine infusion varying from 7 days to 10 days and received subsequent booster infusions varying from one day to 2 days. All the infusion days were limited to 4 hours each day. All the patients reported at least 50% pain relief lasting for more than 4 weeks to 6 weeks. Out of the 52 patients studied, 36 (69%) had returned to work or resumed attending school. Blood liver function tests were performed within 24 hours of the infusion. The liver function tests performed were serum albumin, total protein, total bilirubin, aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase levels. There was no evidence of liver dysfunction in any of the patients following their ketamine infusion.

Limitations: This was a retrospective analysis without a control group.

Conclusions: Intravenous ketamine infusions performed to achieve adequate pain control for CRPS does not alter liver function tests.

本刊更多论文

静脉注射氯胺酮治疗复杂局部疼痛综合征后肝功能的回顾性分析。

背景：复杂局部疼痛综合征（CRPS）是一种严重的疼痛症状，目前有效的治疗方法很少。治疗CRPS的方法之一是静脉注射氯胺酮。关于氯胺酮对肝功能障碍的影响，有一个有争议的轶事报道。目的：研究氯胺酮对肝酶的影响。研究设计：回顾性研究。设置：多地点疼痛管理中心。方法：回顾分析2010年1月至2018年12月治疗期间52例患者的病历资料。所有患者均接受氯胺酮静脉输注治疗CRPS。按照方案，在输注后24小时内进行肝功能检查。布朗大学人类研究保护计划确定，拟议的研究不涉及45 CFR Part 46.102所定义的人类受试者。结果：回顾性图表回顾作为持续质量评估的一部分。所有患者均接受了多天的氯胺酮负荷剂量输注，时间从7天到10天不等，随后接受了1天到2天不等的加强输注。所有的输注时间限制在每天4小时。所有患者均报告疼痛缓解至少50%，持续时间超过4周至6周。在研究的52名患者中，36名（69%）已经重返工作岗位或恢复上学。在输注后24小时内进行血肝功能检查。肝功能检查包括血清白蛋白、总蛋白、总胆红素、天冬氨酸转氨酶、丙氨酸转氨酶和碱性磷酸酶水平。注射氯胺酮后，没有任何患者出现肝功能障碍。局限性：这是一项没有对照组的回顾性分析。结论：静脉氯胺酮输注以达到足够的疼痛控制CRPS不会改变肝功能检查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pain physician CLINICAL NEUROLOGY-CLINICAL NEUROLOGY

CiteScore

6.00

自引率

21.60%

发文量

234

期刊介绍： Pain Physician Journal is the official publication of the American Society of Interventional Pain Physicians (ASIPP). The open access journal is published 6 times a year. Pain Physician Journal is a peer-reviewed, multi-disciplinary, open access journal written by and directed to an audience of interventional pain physicians, clinicians and basic scientists with an interest in interventional pain management and pain medicine. Pain Physician Journal presents the latest studies, research, and information vital to those in the emerging specialty of interventional pain management – and critical to the people they serve.