The impact of exercise on mitochondrial biogenesis in skeletal muscle: A systematic review and meta-analysis of randomized trials.

IF 2.6 Q2 Biochemistry, Genetics and Molecular Biology
Biomolecular Concepts Pub Date : 2025-05-30 eCollection Date: 2025-01-01 DOI:10.1515/bmc-2025-0055
Diana Marisol Abrego-Guandique, Nalia Mercedes Aguilera Rojas, Aldo Chiari, Filippo Luciani, Erika Cione, Roberto Cannataro
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引用次数: 0

Abstract

The interaction between exercise and mitochondrial biogenesis in skeletal muscle is fundamental to human physiology, with important implications for health and athletic performance. While exercise is known to stimulate mitochondrial biogenesis, the effectiveness of varying-intensity exercise remains unclear. This systematic review and meta-analysis aimed to evaluate the impact of physical activity on mitochondrial biogenesis pathways in skeletal muscle and identify key biomolecular markers in healthy individuals. Among these, PGC-1α emerged as the most consistently reported marker. The meta-analysis showed a significant increase in PGC-1α expression following endurance exercise, with a pooled effect size of Hedge's g = 1.17 (95% confidence interval: 0.14-2.19, I 2 = 84.5%), indicating a large effect with substantial heterogeneity. Subgroup analyses revealed that both interval and continuous endurance training produced large effects (Hedge's g = 1.29 and 1.01, respectively), with no significant difference between modalities (p > 0.05). These findings confirm that exercise induces significant molecular and structural mitochondrial adaptations, with responses influenced by exercise type, intensity, and duration. This underscores exercise as a potent stimulus for mitochondrial biogenesis, supporting its role in promoting metabolic health and physical performance.

运动对骨骼肌线粒体生物发生的影响:随机试验的系统回顾和荟萃分析。
运动与骨骼肌线粒体生物发生之间的相互作用是人体生理学的基础,对健康和运动表现具有重要意义。虽然已知运动可以刺激线粒体的生物生成,但不同强度运动的有效性尚不清楚。本系统综述和荟萃分析旨在评估体育活动对骨骼肌线粒体生物发生途径的影响,并确定健康个体的关键生物分子标记。其中,PGC-1α是最一致报道的标记物。荟萃分析显示,耐力运动后PGC-1α表达显著增加,合并效应大小为Hedge's g = 1.17(95%置信区间:0.14-2.19,i2 = 84.5%),表明影响较大,异质性显著。亚组分析显示,间歇和连续耐力训练都产生了很大的影响(Hedge’s g分别= 1.29和1.01),不同训练方式之间没有显著差异(p < 0.05)。这些发现证实,运动诱导了显著的分子和线粒体结构适应,其反应受运动类型、强度和持续时间的影响。这强调了运动是线粒体生物发生的有力刺激,支持其在促进代谢健康和身体表现方面的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomolecular Concepts
Biomolecular Concepts Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
5.30
自引率
0.00%
发文量
27
审稿时长
12 weeks
期刊介绍: BioMolecular Concepts is a peer-reviewed open access journal fostering the integration of different fields of biomolecular research. The journal aims to provide expert summaries from prominent researchers, and conclusive extensions of research data leading to new and original, testable hypotheses. Aspects of research that can promote related fields, and lead to novel insight into biological mechanisms or potential medical applications are of special interest. Original research articles reporting new data of broad significance are also welcome. Topics: -cellular and molecular biology- genetics and epigenetics- biochemistry- structural biology- neurosciences- developmental biology- molecular medicine- pharmacology- microbiology- plant biology and biotechnology.
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