Choroid plexus area and choroid plexus /lateral ventricle area index are potential imaging markers for freezing of gait in Parkinson's disease

IF 5.1 2区医学 Q1 NEUROSCIENCES

Neurobiology of Disease Pub Date : 2025-06-02 DOI:10.1016/j.nbd.2025.106984

Xi Yin , Miao Wang , Fenqiang Zhao , Fengzhu Li , Yuxing Tang , Xiaoyu Wang , Caohui Duan , Song Wang , Yongqin Xiong , Jiarui Yao , Tong Chen , Zhenfu Wang , Yifan Li , Xin Lou , Zhongbao Gao

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引用次数: 0

Abstract

Background

The choroid plexus (CP), an important structure involved in cerebrospinal fluid (CSF) circulation, plays a key role in clearing harmful metabolites from the brain. However, the relationship between CP and the development of Parkinson's disease (PD) remains unclear, especially in those with freezing of gait (FOG). We aim to investigate the association between the CP area and CP/lateral ventricle area (CP/Ven) index with clinical symptoms of PD and the development of FOG.

Methods

Seventy-three patients with PD (17 with FOG and 56 without FOG) and 49 healthy controls (HCs) underwent 7 T magnetic resonance imaging and neurological assessments. The CP area and CP/Ven index were calculated, and the differences across groups were compared. Spearman's rank correlation was used to evaluate associations between these indices and clinical scales. Binary logistic regression was used to explore the impact of the CP area and CP/Ven index on FOG occurrence in PD.

Results

Patients with FOG (PD-FOG) exhibited significantly higher CP area and CP/Ven index than those without FOG (PD-nFOG). Both the CP area and CP/Ven index were positively correlated with the PD motor scale scores, especially postural instability/gait disturbance. Receiver operating characteristic curve analysis showed that the CP area and CP/Ven index effectively distinguished PD-FOG from PD-nFOG, with area under curve of 0.887 and 0.854, respectively. Logistic regression analysis confirmed that both indices independently increased the risk of FOG in PD.

Conclusion

Elevated CP area and CP/Ven index are novel, noninvasive neuroimaging markers of FOG in PD.

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脉络膜丛面积和脉络膜丛/侧脑室面积指数是帕金森病步态冻结的潜在影像学指标

脉络丛（CP）是脑脊液（CSF）循环中的一个重要结构，在清除大脑有害代谢物中起着关键作用。然而，CP与帕金森病（PD）发展之间的关系尚不清楚，特别是在步态冻结（FOG）患者中。我们旨在探讨脑室面积和脑室/侧脑室面积（CP/Ven）指数与PD的临床症状和FOG的发展之间的关系。方法对73例PD患者（17例有FOG， 56例无FOG）和49例健康对照（hc）进行7t磁共振成像和神经学评估。计算CP面积和CP/Ven指数，比较各组间差异。Spearman等级相关用于评价这些指标与临床量表之间的相关性。采用二元logistic回归探讨CP面积和CP/Ven指数对PD中FOG发生的影响。结果FOG （PD-FOG）患者的CP面积和CP/Ven指数明显高于非FOG （PD-nFOG）患者。CP面积和CP/Ven指数均与PD运动量表得分呈正相关，尤其是姿势不稳定/步态障碍。受试者工作特征曲线分析表明，CP面积和CP/Ven指数能有效区分PD-FOG和PD-nFOG，曲线下面积分别为0.887和0.854。Logistic回归分析证实，这两项指标均独立增加PD患者发生FOG的风险。结论CP面积升高和CP/Ven指数升高是一种新的、无创的PD FOG神经影像学指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurobiology of Disease 医学-神经科学

CiteScore

11.20

自引率

3.30%

发文量

270

审稿时长

76 days

期刊介绍： Neurobiology of Disease is a major international journal at the interface between basic and clinical neuroscience. The journal provides a forum for the publication of top quality research papers on: molecular and cellular definitions of disease mechanisms, the neural systems and underpinning behavioral disorders, the genetics of inherited neurological and psychiatric diseases, nervous system aging, and findings relevant to the development of new therapies.