Potential anticancer therapeutic targets of resveratrol and its role in the therapy of hepatocellular carcinoma

IF 4.8 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Food Bioscience Pub Date : 2025-05-26 DOI:10.1016/j.fbio.2025.106935

Wasnaa H. Mohammed , Ghassan M. Sulaiman , Hamdoon A. Mohammed

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引用次数: 0

Abstract

Resveratrol (RES) is a stilbene natural phytoestrogen with anti-cancer, antioxidant, cardioprotective, and anti-inflammatory properties. This review explores the therapeutic potential of RES in hepatocellular carcinoma (HCC) by emphasizing its mechanisms of action. Plant-based natural sources of RES, such as cereals, fruits, and vegetables, have been found to be effective and safe in treating various illnesses, including cancer and inflammation. Literature suggested that RES may protect the liver from developing hepatocellular carcinoma (HCC) in its early stages. The compound also induces apoptosis in abnormally growing hepatocytes. Moreover, RES also significantly reduces angiogenesis and metastasis, which are two hallmarks of advanced cancer stages. RES caused apoptosis and prevented HCC cell lines (HepG2) from proliferating, migrating, and invading. Additionally, RES has been shown to greatly enhance the effectiveness of chemotherapy drugs by working together with them and making cancer cells more sensitive to treatment. Therefore, several targets have been connected to RES as molecular mechanisms by which the compound induces combat against hepatocellular carcinoma (HCC). This review discusses RES's natural sources, biosynthesis, bioavailability, and improved synthetic derivatives, as well as a comprehensive overview of the metabolic and cellular signaling pathways influenced by RES in HCC. The review also discussed the beneficial role of RES in liver disorders. We also want to identify future studies that will maximize the therapeutic potential of RES in HCC.

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白藜芦醇的潜在抗癌靶点及其在肝癌治疗中的作用

白藜芦醇（Resveratrol， RES）是一种苯乙烯类天然植物雌激素，具有抗癌、抗氧化、保护心脏和抗炎等特性。本文通过强调其作用机制，探讨了RES在肝细胞癌（HCC）中的治疗潜力。以植物为基础的天然RES来源，如谷物、水果和蔬菜，已被发现在治疗包括癌症和炎症在内的各种疾病方面有效且安全。文献表明，RES可能保护肝脏免受早期肝细胞癌（HCC）的发展。该化合物还能诱导异常生长的肝细胞凋亡。此外，RES还显著减少血管生成和转移，这是癌症晚期的两个标志。RES引起细胞凋亡，阻止HCC细胞系（HepG2）增殖、迁移和侵袭。此外，RES已被证明可以通过与化疗药物共同作用，使癌细胞对治疗更敏感，从而大大提高化疗药物的有效性。因此，一些靶点已被连接到RES作为分子机制，通过该化合物诱导对抗肝细胞癌（HCC）。本文综述了RES的天然来源、生物合成、生物利用度和改进的合成衍生物，并全面概述了RES在HCC中影响的代谢和细胞信号通路。本文还讨论了RES在肝脏疾病中的有益作用。我们还希望确定未来的研究，以最大限度地发挥RES在HCC中的治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food Bioscience Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

6.40

自引率

5.80%

发文量

671

审稿时长

27 days

期刊介绍： Food Bioscience is a peer-reviewed journal that aims to provide a forum for recent developments in the field of bio-related food research. The journal focuses on both fundamental and applied research worldwide, with special attention to ethnic and cultural aspects of food bioresearch.