Multi-model risk assessment of pesticide residues in seasonal fruits based on integrated targeted/non-targeted screening: Implications for vulnerable populations

IF 6.5 1区农林科学 Q1 CHEMISTRY, APPLIED

Food Chemistry: X Pub Date : 2025-05-01 DOI:10.1016/j.fochx.2025.102599

Wenshuai Si , Yiqing Song , Can Guo , Zhiying Huang , Lei Chen , Fei Xu , Bing Bai , Kaixuan Huo , Shouying Wang

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引用次数: 0

Abstract

This study comprehensively analyzed multiple pesticide residues and their characteristics in commercially available fruits using integrated targeted and non-targeted techniques, with a focus on assessing health risks for children and pregnant women based on cumulative dietary risk models. Results showed 745 samples (7 categories) identified 54 pesticides (88.6 % detection rate; 1.1 % exceeding legal limits), with strawberries and peaches of the highest detection rates (98 %), and grapes the most diverse residues (avg. 6/sample). Risk ranking analysis flagged difenoconazole and indoxacarb as high-risk. Chronic cumulative exposure risks were dominated by hepatotoxic triazole fungicides. Acute risk assessments revealed potential hepatotoxicity concerns for children (3–6 years) and pregnant women consuming grapes/peaches. The Relative Potency Factor (RPF) model, accounting for synergism, showed 4–7 times higher neuro/hepatotoxicity risks than the Hazard Index (HI) model. This first integration of non-targeted screening with multi-model risk assessment provides evidence for strengthening pesticide regulation and protecting sensitive subpopulations.

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基于综合目标/非目标筛选的时令水果农药残留多模型风险评估：对脆弱人群的影响

本研究采用综合定向和非定向技术，综合分析了市售水果中多种农药残留及其特征，重点评估了基于累积饮食风险模型的儿童和孕妇的健康风险。结果：745份样品（7大类）鉴定出54种农药，检出率为88.6%；其中草莓和桃子的检出率最高（98%），葡萄的残留物种类最多（平均每样6个）。风险排名分析将异虫康唑和茚虫威标记为高风险。慢性累积暴露风险以肝毒性三唑类杀菌剂为主。急性风险评估显示，食用葡萄/桃子的儿童（3-6岁）和孕妇可能存在肝毒性问题。考虑到协同作用，相对效力因子（RPF）模型显示的神经/肝毒性风险比危害指数（HI）模型高4-7倍。这是首次将非靶向筛查与多模型风险评估相结合，为加强农药监管和保护敏感亚群提供了证据。

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来源期刊

Food Chemistry: X CHEMISTRY, APPLIED-

CiteScore

4.90

自引率

6.60%

发文量

315

审稿时长

55 days

期刊介绍： Food Chemistry: X, one of three Open Access companion journals to Food Chemistry, follows the same aims, scope, and peer-review process. It focuses on papers advancing food and biochemistry or analytical methods, prioritizing research novelty. Manuscript evaluation considers novelty, scientific rigor, field advancement, and reader interest. Excluded are studies on food molecular sciences or disease cure/prevention. Topics include food component chemistry, bioactives, processing effects, additives, contaminants, and analytical methods. The journal welcome Analytical Papers addressing food microbiology, sensory aspects, and more, emphasizing new methods with robust validation and applicability to diverse foods or regions.