The memory- and cognition-facilitating effects of spermidine in aging and aging-related disorders

IF 12.4 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2025-05-28 DOI:10.1016/j.arr.2025.102787

Mengjie Zou , Dan Li , Yi Yang

引用次数: 0

Abstract

Spermidine is a natural polyamine found in living organisms. In human, the level of spermidine declines with aging. Emerging lines of evidence indicates that supplementation of spermidine favors the improvement of memory performance and cognition function. In this article, recent findings regarding the metabolism of spermidine under pathophysiological conditions are discussed. This review emphasizes the recent mechanistic insights into the memory- and cognition-facilitating effects of spermidine, specifically detailing autophagy induction, mitochondrial protection, synaptic maintenance and other aspects. Recent advances in understanding the precise role of spermidine may shed light on the prevention and treatment of aging-associated memory and cognitive decline.

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亚精胺在衰老和衰老相关疾病中的记忆和认知促进作用

亚精胺是一种存在于生物体中的天然多胺。在人体中，亚精胺的水平随着年龄的增长而下降。越来越多的证据表明，补充亚精胺有利于改善记忆表现和认知功能。本文就亚精胺在病理生理条件下的代谢研究进展作一综述。本文综述了近年来亚精胺对记忆和认知促进作用的机制研究进展，重点介绍了自噬诱导、线粒体保护、突触维持等方面的研究进展。在了解亚精胺的确切作用方面的最新进展可能有助于预防和治疗与衰老相关的记忆和认知能力下降。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.