High histamine expression by early-stage squamous cell carcinoma of the tongue is associated with a poor prognosis.

IF 2.5 4区生物学 Q3 CELL BIOLOGY

Histology and histopathology Pub Date : 2025-05-14 DOI:10.14670/HH-18-938

Satoshi Kimura, Hirotsugu Noguchi, Hiroaki Sato, Shohei Shimajiri, Toshiyuki Nakayama

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引用次数: 0

Abstract

Background: Although not widely known, several types of cancers express histamine. Squamous cell carcinoma (SCC) of the tongue is one such cancer, and histamine expression is associated with the tumor microenvironment. Our aim was to examine whether histamine expression is a useful prognostic factor for tongue SCC.

Methods: Histamine cannot be accurately measured directly because it is rapidly degraded after secretion. Therefore, L-histidine decarboxylase (HDC), an enzyme that synthesizes histamine in a single step, was used to estimate histamine secretion. In a retrospective study, tongue SCC samples from patients were immunohistochemically stained for HDC; the staining intensity was semi-quantified and evaluated relative to indices used in histopathological diagnosis.

Results: High expression of HDC was associated with the worst tumor invasion and tumor budding. Overall survival curves revealed that patients with tongue SCC showing high HDC expression had a poor prognosis.

Conclusion: The expression of histamine may be a prognostic indicator for tongue SCC.

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早期舌鳞状细胞癌的高组胺表达与预后不良有关。

背景：虽然不为人所知，但有几种类型的癌症表达组胺。舌鳞状细胞癌（SCC）就是这样一种癌症，组胺的表达与肿瘤微环境有关。我们的目的是研究组胺表达是否是舌鳞状细胞癌的一个有用的预后因素。方法：组胺分泌后降解迅速，不能直接准确测定。因此，l -组氨酸脱羧酶（HDC）是一种单步合成组胺的酶，被用来估计组胺的分泌。在一项回顾性研究中，对患者舌鳞癌样本进行HDC免疫组织化学染色；染色强度是半量化的，并相对于组织病理学诊断的指标进行评估。结果：HDC高表达与恶性肿瘤侵袭及肿瘤出芽有关。总体生存曲线显示，HDC高表达的舌鳞癌患者预后较差。结论：组胺表达可能是舌鳞状细胞癌的预后指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Histology and histopathology 生物-病理学

CiteScore

3.90

自引率

0.00%

发文量

232

审稿时长

2 months

期刊介绍： HISTOLOGY AND HISTOPATHOLOGY is a peer-reviewed international journal, the purpose of which is to publish original and review articles in all fields of the microscopical morphology, cell biology and tissue engineering; high quality is the overall consideration. Its format is the standard international size of 21 x 27.7 cm. One volume is published every year (more than 1,300 pages, approximately 90 original works and 40 reviews). Each volume consists of 12 numbers published monthly online. The printed version of the journal includes 4 books every year; each of them compiles 3 numbers previously published online.