Assessing the impact of transcranial electrical stimulation on intracranial and cerebral perfusion pressures in patients with severe craniocerebral injury: A novel methodological approach

IF 2.7 4区医学 Q2 BIOCHEMICAL RESEARCH METHODS

Journal of Neuroscience Methods Pub Date : 2025-05-26 DOI:10.1016/j.jneumeth.2025.110498

Ailiang Ge, Jinan Bai, Yan Wang, Xin Li

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引用次数: 0

Abstract

Background

Transcranial electrical stimulation (tES) protects brain cells and blood flow, making it an intriguing treatment option for skull and brain injury victims. Understanding how transcranial electroencephalography (tES) affects cerebral perfusion pressure (CPP) and intracranial pressure (ICP) might improve patient outcomes. Most techniques for evaluating ICP and CPP include intrusive procedures that might cause infections and hiccups. Additionally, current methods cannot optimize patient results by changing stimulation settings in real-time.

New Method

The Optimizing tES Parameters for Neuroprotection (O-tES-PN) approach addresses these issues. The system has many monitoring tools and an adaptive tES control mechanism. The O-tES-PN continually adjusts its dynamic stimulation settings based on intracranial and cerebral blood pressure. This keeps cerebral blood flow constant and reduces damage.

Results

Our findings show that stable ICP and CPP enhance CBF modulation with the O-tES-PN design. The device may modify settings in real-time to give more concentrated and effective treatments with fewer adverse effects.

Comparison with Existing Methods

Compared to invasive therapies, O-tES-PN is safer. It also improves therapy parameter control. Current technology allows continuous monitoring and stimulation level changes, which are limitations of previous systems.

Conclusions

The O-tES-PN treatment is less risky than other invasive treatments. Controlling the parameters of the treatment is also improved. The limitations of earlier systems are overcome by the current technology, which enables continuous monitoring and adjustments in stimulation level.

查看原文本刊更多论文

评估经颅电刺激对重型颅脑损伤患者颅内和脑灌注压的影响：一种新的方法方法。

背景：经颅电刺激（tES）保护脑细胞和血液流动，使其成为颅脑损伤患者的一种有趣的治疗选择。了解经颅脑电图（tES）如何影响脑灌注压（CPP）和颅内压（ICP）可能会改善患者的预后。大多数评估ICP和CPP的技术包括可能导致感染和打嗝的侵入性程序。此外，目前的方法不能通过实时改变刺激设置来优化患者的结果。新方法：优化神经保护tES参数（O-tES-PN）方法解决了这些问题。该系统具有多种监控工具和自适应tES控制机制。O-tES-PN根据颅内压和脑压不断调整其动态刺激设置。这样可以保持脑血流量恒定，减少损伤。结果：我们的研究结果表明，稳定的ICP和CPP通过O-tES-PN设计增强了CBF调制。该设备可以实时修改设置，以提供更集中和有效的治疗，减少不良反应。与现有方法比较：与侵入性治疗相比，o - es - pn更安全。它还改善了治疗参数的控制。目前的技术允许连续监测和增产水平变化，这是以前系统的局限性。结论：o - es - pn治疗风险低于其他有创治疗。对处理参数的控制也进行了改进。目前的技术克服了早期系统的局限性，可以连续监测和调整增产水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neuroscience Methods 医学-神经科学

CiteScore

7.10

自引率

3.30%

发文量

226

审稿时长

52 days

期刊介绍： The Journal of Neuroscience Methods publishes papers that describe new methods that are specifically for neuroscience research conducted in invertebrates, vertebrates or in man. Major methodological improvements or important refinements of established neuroscience methods are also considered for publication. The Journal''s Scope includes all aspects of contemporary neuroscience research, including anatomical, behavioural, biochemical, cellular, computational, molecular, invasive and non-invasive imaging, optogenetic, and physiological research investigations.