Striatal cue-reactivity and neurotransmitter function in gambling disorder.

IF 6.2 1区 医学 Q1 PSYCHIATRY
Journal of Behavioral Addictions Pub Date : 2025-05-28 Print Date: 2025-07-02 DOI:10.1556/2006.2025.00041
Albert Bellmunt-Gil, Joonas Majuri, Lauri Nummenmaa, Semi Helin, Sarita Forsback, Johan Rajander, Valtteri Kaasinen, Juho Joutsa
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引用次数: 0

Abstract

Background: Abnormal striatal cue reactivity is one of the neurobiological hallmarks of substance use disorders (SUDs). Cue reactivity is associated with relapse, prompting efforts to target its underlying mechanisms with therapeutic interventions. However, the neural correlates of cue reactivity in behavioral addictions, such as gambling disorder (GD), remain poorly understood. Here we investigated striatal cue reactivity and its associations with neurotransmitters in individuals with GD using multimodal neuroimaging.

Methods: Thirteen subjects with GD and 16 healthy controls (HC) underwent fMRI using a block-design consisting of three different types of visual stimuli: gambling-related, erotic, and neutral videos. The subjects also underwent brain PET imaging with three radiotracers to assess dopamine ([18F]FDOPA), opioid ([11C]carfentanil) and serotonin ([11C]MADAM) function.

Results: GD subjects showed a significantly greater BOLD response in the dorsal striatum compared to HC when viewing gambling-related versus neutral videos (pFWE<0.05). Enhanced cue-reactivity was specific to gambling, as there were no significant differences between the groups with natural reward cues (erotic vs. neutral videos). The dorsal and ventral striatum BOLD responses to gambling videos were coupled in HC (r = 0.7, p = 0.003) but not in GD (r = -0.1, p = 0.75; group difference p = 0.008). In GD, dorsal striatal BOLD response to gambling cues correlated with [11C]carfentanil, but not with [18F]FDOPA or [11C]MADAM, binding (r = 0.8, p < 0.001).

Conclusions: GD is characterized by increased gambling cue-induced activity in the dorsal striatum, which is linked to mu-opioid receptor availability. The findings highlight the potential role of the mu-opioid system in mediating cue-reactivity in behavioral addictions.

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赌博障碍的纹状体线索反应性和神经递质功能。
背景:纹状体线索反应异常是物质使用障碍(sud)的神经生物学标志之一。提示反应性与复发有关,促使人们努力针对其潜在机制进行治疗干预。然而,行为成瘾(如赌博障碍(GD))中线索反应的神经相关性仍然知之甚少。在这里,我们研究纹状体线索反应性及其与神经递质在GD个体使用多模态神经成像的关系。方法:13名GD受试者和16名健康对照(HC)使用由三种不同类型的视觉刺激组成的块组设计进行功能磁共振成像:赌博相关视频,色情视频和中性视频。受试者还接受了三种放射性示踪剂的脑PET成像,以评估多巴胺([18F]FDOPA)、阿片类药物([11C]卡芬太尼)和血清素([11C]MADAM)的功能。结果:与HC相比,GD受试者在观看与赌博相关的视频时,其背纹状体的BOLD反应明显更强。结论:GD的特点是赌博线索诱导的背纹状体活动增加,这与mu-阿片受体的可用性有关。这些发现强调了多阿片系统在行为成瘾中介导线索反应的潜在作用。
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来源期刊
CiteScore
12.30
自引率
7.70%
发文量
91
审稿时长
20 weeks
期刊介绍: The aim of Journal of Behavioral Addictions is to create a forum for the scientific information exchange with regard to behavioral addictions. The journal is a broad focused interdisciplinary one that publishes manuscripts on different approaches of non-substance addictions, research reports focusing on the addictive patterns of various behaviors, especially disorders of the impulsive-compulsive spectrum, and also publishes reviews in these topics. Coverage ranges from genetic and neurobiological research through psychological and clinical psychiatric approaches to epidemiological, sociological and anthropological aspects.
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