Assessment of thiamine status and its association with clinical parameters in patients undergoing maintenance hemodialysis.

IF 4 2区农林科学 Q2 NUTRITION & DIETETICS

Frontiers in Nutrition Pub Date : 2025-05-14 eCollection Date: 2025-01-01 DOI:10.3389/fnut.2025.1563768

Bo Yang, Naiying Lan, Fanzhou Zeng, Qing Shao, Dan Ye, Hao Wang, Cheng Xue, Nanmei Liu

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引用次数: 0

Abstract

Objective: Thiamine deficiency is a common complication in end-stage renal disease (ESRD) patients receiving maintenance hemodialysis (HD). The purpose of this cross-sectional study was to assess the prevalence of thiamine deficiency in HD patients and its association with clinical parameters.

Methods: This was a single-center cross-sectional study that included 113 maintenance HD patients from our hospital. Thiamine status was evaluated by high-performance liquid chromatography on whole blood samples. We evaluated the association between blood thiamine concentration and other clinical parameters, including markers of iron metabolism and cardiac function.

Results: The prevalence of thiamine deficiency was 11.5%. Univariate analysis revealed a significant positive correlation between thiamine levels and iron metabolism markers, including hemoglobin level (Rho = 0.257, p = 0.006), transferrin saturation (Rho = 0.244, p = 0.009), and serum iron (Rho = 0.213, p = 0.025). A multivariate regression analysis confirmed that thiamine levels were independently associated with hemoglobin levels (beta coefficients = 0.25, p = 0.012).

Conclusion: These findings suggest an association between lower thiamine levels and anemia in HD patients. Further research is needed to elucidate the underlying mechanisms and evaluate the efficacy of thiamine supplementation in improving anemia and other clinical outcomes in this population.

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维持性血液透析患者硫胺素状态及其与临床参数的关系评估。

目的：硫胺素缺乏是终末期肾病（ESRD）患者接受维持性血液透析（HD）的常见并发症。本横断面研究的目的是评估HD患者中硫胺素缺乏症的患病率及其与临床参数的关系。方法：本研究为单中心横断面研究，纳入我院113例维持性HD患者。采用高效液相色谱法测定全血样品的硫胺素状态。我们评估了血硫胺素浓度与其他临床参数之间的关系，包括铁代谢和心功能的标志物。结果：硫胺素缺乏症患病率为11.5%。单变量分析发现硫胺素之间显著正相关水平和铁代谢标记,包括血红蛋白水平(ρ = 0.257,p = 0.006),转铁蛋白饱和度(ρ = 0.244,p = 0.009),血清铁(ρ = 0.213,p = 0.025)。多变量回归分析证实硫胺素水平与血红蛋白水平独立相关（β系数 = 0.25,p = 0.012）。结论：这些发现提示了低硫胺素水平与HD患者贫血之间的关联。需要进一步的研究来阐明潜在的机制，并评估补充硫胺素在改善该人群贫血和其他临床结果方面的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Nutrition Agricultural and Biological Sciences-Food Science

CiteScore

5.20

自引率

8.00%

发文量

2891

审稿时长

12 weeks

期刊介绍： No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health. Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.