Cogwheel rigidity in Parkinson's disease: Clinical, biomechanical and neurophysiological features

IF 5.1 2区医学 Q1 NEUROSCIENCES

Neurobiology of Disease Pub Date : 2025-05-28 DOI:10.1016/j.nbd.2025.106980

Marco Falletti , Francesco Asci , Alessandro Zampogna , Martina Patera , Antonio Suppa

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引用次数: 0

Abstract

Objectives

Cogwheel rigidity in Parkinson's disease has been poorly investigated so far, thus leaving the scientific interpretation of this phenomenon substantially unsolved. A detailed clinical, biomechanical and neurophysiological investigation would clarify the pathophysiological underpinning of cogwheel rigidity.

Methods

Patients underwent robot-assisted wrist extensions at various angular velocities, when OFF and ON therapies. For each value of angular velocity, several biomechanical (i.e. elastic, viscous and neural components) and neurophysiological measures (i.e. long-latency stretch reflex) were synchronously assessed and correlated with the clinical score of rigidity (i.e. Movement Disorder Society Unified Parkinson's Disease Rating Scale—part III, subitems for the upper limb).

Results

A total of 18 PD patients participated. Patients were divided into two groups according to the presence of cogwheel rigidity at the clinical examination (CWR and No-CWR, respectively). CWR patients had a longer disease duration, greater motor severity and disability scores compared to those who did not. Biomechanical (NC and TF) and neurophysiological data (LLRs amplitude and AUC) also disclosed a more pronounced impairment in patients with cogwheel rigidity. L-DOPA comparably improved rigidity measures in patients with and without cogwheel rigidity.

Discussion

Cogwheel rigidity may be associated with prominent impairment in clinical, biomechanical, and neurophysiological features of rigidity in patients with PD. Future studies in larger cohorts are needed to achieve more firm conclusions.

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帕金森病的齿轮刚性：临床、生物力学和神经生理特征

目的到目前为止，对帕金森病的齿轮刚性研究甚少，因此对这一现象的科学解释基本上没有得到解决。详细的临床、生物力学和神经生理学研究将阐明齿轮刚性的病理生理基础。方法患者在OFF和ON治疗时接受机器人辅助的不同角速度的手腕伸展。对于每个角速度值，同步评估几种生物力学（即弹性，粘性和神经成分）和神经生理指标（即长潜伏期拉伸反射），并与僵硬的临床评分（即运动障碍学会统一帕金森病评定量表-第III部分，上肢子项）相关联。结果共18例PD患者参与。根据临床检查时是否存在齿轮刚性将患者分为两组（CWR组和No-CWR组）。与没有CWR的患者相比，CWR患者的疾病持续时间更长，运动严重程度和残疾评分更高。生物力学（NC和TF）和神经生理学数据（llr振幅和AUC）也揭示了齿轮刚性患者更明显的损伤。左旋多巴可比较地改善有和无齿轮刚性的患者的刚性测量。齿轮刚性可能与PD患者的临床、生物力学和神经生理特征的显著损害有关。未来需要更大规模的研究来得出更确定的结论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurobiology of Disease 医学-神经科学

CiteScore

11.20

自引率

3.30%

发文量

270

审稿时长

76 days

期刊介绍： Neurobiology of Disease is a major international journal at the interface between basic and clinical neuroscience. The journal provides a forum for the publication of top quality research papers on: molecular and cellular definitions of disease mechanisms, the neural systems and underpinning behavioral disorders, the genetics of inherited neurological and psychiatric diseases, nervous system aging, and findings relevant to the development of new therapies.