Immune-Enhancing Effects of Two Potential Probiotic Strains Latilactobacillus curvatus WiKim0169 and Pediococcus acidilactici WiKim0170 in a Cyclophosphamide-Induced Immunosuppression Rat Model.

IF 4.4 2区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Probiotics and Antimicrobial Proteins Pub Date : 2025-05-27 DOI:10.1007/s12602-025-10585-4

Eun-Jung Park, You-Suk Lee, Eun-Min Jun, Byung Wook Lee, Sang Min Park, Hae-Jeung Lee

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引用次数: 0

Abstract

Emerging evidence suggests that probiotics are beneficial for immunity and play a crucial role in regulating gut microbiota. However, the immune-enhancing effects of specific bacterial species remain uncertain. This study investigated the effects of two potential probiotic strains, Latilactobacillus curvatus WiKim0169 (Wilac L004, W4) and Pediococcus acidilactici WiKim0170 (Wilac L002, W2) isolated from fermented cabbage, on immune enhancement and gut microbiota changes in a cyclophosphamide-induced immunosuppression rat model. The results revealed that W4 and W2 improved natural killer cell activity, serum nitrite, and immunoglobulin levels. They also increased cytokine levels and activated the nuclear factor-κB pathway, substantiating the underlying mechanism of the immune-enhancing effects. Additionally, both strains altered gut microbiota composition by increasing bacteria that are being studied for their potential association with immune function. Taken together, both strains improved immune-related biomarkers and the gut microbiota. These findings suggest W4 and W2 as promising probiotics with immune-enhancing properties.

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两种潜在的益生菌菌株弯曲乳酸杆菌WiKim0169和酸化Pediococcus WiKim0170在环磷酰胺诱导的免疫抑制大鼠模型中的免疫增强作用

越来越多的证据表明，益生菌对免疫有益，在调节肠道微生物群中起着至关重要的作用。然而，特定细菌种类的免疫增强作用仍然不确定。本研究研究了从发酵白菜中分离的两种潜在益生菌——弯曲乳酸杆菌WiKim0169 （Wilac L004, W4）和酸化Pediococcus WiKim0170 （Wilac L002, W2）对环磷酰胺诱导的免疫抑制大鼠模型的免疫增强和肠道菌群变化的影响。结果显示，W4和W2可提高自然杀伤细胞活性、血清亚硝酸盐和免疫球蛋白水平。它们还增加了细胞因子水平，激活了核因子-κB通路，证实了免疫增强作用的潜在机制。此外，这两种菌株通过增加细菌来改变肠道菌群组成，目前正在研究它们与免疫功能的潜在关联。总之，这两种菌株都改善了免疫相关的生物标志物和肠道微生物群。这些发现表明W4和W2是有希望的具有免疫增强特性的益生菌。

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来源期刊

Probiotics and Antimicrobial Proteins BIOTECHNOLOGY & APPLIED MICROBIOLOGYMICROB-MICROBIOLOGY

CiteScore

11.30

自引率

6.10%

发文量

140

期刊介绍： Probiotics and Antimicrobial Proteins publishes reviews, original articles, letters and short notes and technical/methodological communications aimed at advancing fundamental knowledge and exploration of the applications of probiotics, natural antimicrobial proteins and their derivatives in biomedical, agricultural, veterinary, food, and cosmetic products. The Journal welcomes fundamental research articles and reports on applications of these microorganisms and substances, and encourages structural studies and studies that correlate the structure and functional properties of antimicrobial proteins.